Tamburro Symposium on Environmental Chemicals and Liver Disease

描述(由申请人提供) 肝脏是最大的内脏器官，也是最复杂的，因为它调节异物和能量代谢。然而，肝病越来越常见，目前以人群为基础的研究表明，超过三分之一的成年人和超过10%的儿童患有慢性肝病。据推测，由于其在异物代谢中的作用，肝脏是靶标。 最常受环境化学物质影响的器官。然而，环境暴露在当前肝病流行中的作用同时也没有得到临床医生和科学研究界的充分认识。本次申请的主要目的是举办为期两天的“环境化学品与肝病”研讨会。在过去的五年中，没有关于环境肝病新兴领域的全面会议(如果有的话)。已经招募了一个由教职员工组成的专家小组，并计划举办26场讲座和一次海报会议。值得注意的是，已经招募了具有不同专业背景(从临床肝病专家到环境健康基础科学家)的教职员工。女性和少数族裔调查人员也有很好的代表。为了制定一项全面的战略来推动环境肝病领域的发展，有必要首先召集原本不会相互作用的专家来讨论当前的机械性数据并确定知识差距。为此，预计将有100多名来自工业界、学术界(包括学生和早期调查人员)和政府的与会者。会议记录将发表在一份科学期刊上。本次研讨会与所有关心肝病患者或从事肝病或环境健康科学研究的内科医生或科学家有关。

DESCRIPTION (provided by applicant) The liver is the largest internal organ and also the most complex as it regulates xenobiotic and energy metabolism. However, liver disease is increasingly common, and current population-based studies indicate that greater than 1/3 of adults and greater than 10% of children have chronic liver disease. Presumably due to its role in xenobiotic metabolism, the liver is the target organ most commonly affected by environmental chemicals. However, the role of environmental exposures in the current liver disease epidemic is simultaneously under-recognized by clinicians and understudied by the scientific research community. The primary objective of this application is to hold a two-day symposium on "Environmental Chemicals and Liver Disease". There have been no comprehensive conferences in the last five years (if ever) on the emerging field of environmental hepatology. An expert panel of faculty participants has been recruited and 26 lectures and a poster session are planned. Notably, faculty participants with diverse professional backgrounds (ranging from clinical hepatologists to environmental health basic scientists) have been recruited. Female and minority investigators are also well-represented. In order to develop a comprehensive strategy to move the field of environmental hepatology forward, it is necessary to first assemble experts who would otherwise not interact with each other to discuss current mechanistic data and identify knowledge gaps. To this end, greater than 100 attendees from industry, academics (including students and early stage investigators), and government are expected. Conference proceedings will be published in a scientific journal. This symposium is relevant to all physicians or scientists who either care for patients with liver disease or perform research in liver disease or environmental health science.