Mentoring Translational Research in HIV

描述(由申请人提供)：虽然继续取得重大进展，但不太可能很快开发出安全有效的艾滋病毒治疗方法或疫苗。这些目标的成功将取决于未来的艾滋病毒研究人员，他们中的许多人可能在未来五到十年内接受培训。这项K24提案的目的是为申请者在最先进的翻译和以患者为导向的艾滋病毒研究方面向受训学员提供足够的支持，并扩大他对加州大学圣地亚哥分校广泛的培训计划的参与。这一应用程序建立在资助的、积极的和正在进行的研究项目的基础上，在这些项目中，被辅导者是主要领导者，并在研究设计、执行、分析、结果解释和发表的各个方面接受培训。目前的研究为深入指导和研究艾滋病毒发病机制中的重要和公开的科学问题提供了机会。这些目标将在以下三个目标中实现，其中包括多项临床研究和六名当前的受试者。特异性目的1：通过研究生殖道(1A)、肠道相关淋巴组织(1B)和血液中的中和抗体反应(1C)，确定HIV原发感染过程中的病毒学和免疫学动力学。具体目标2：在资源有限的情况下验证用于诊断目的的汇集方法，以检测：抗逆转录病毒治疗的病毒学失败(2A)和艾滋病毒感染情况下的亚急性疟疾感染(2B)。具体目的3：用分子流行病学方法描述圣地亚哥和提华纳之间的HIV-1传播网络。综上所述，这项建议将允许职业生涯中期的申请者继续并扩大他的艾滋病毒研究和指导活动。

DESCRIPTION (provided by applicant): While significant progress continues to be made, it is not likely that a safe and effective cure or vaccine for HIV will be developed soon. The success of these goals will depend on future HIV researchers, many of whom are likely to be trained in the next five to ten years. The goal of this K24 proposal is to provide the applicant with sufficiet support to mentor trainees in state-of-the-art translational and patient oriented HIV research and to expand his involvement in UCSD's wide array of training programs. This application is built upon funded, active and ongoing research projects, where the mentee is the primary leader and is trained in every aspect of study design, execution, analyses, results interpretation and publication. The presented studies provide opportunities for in-depth mentoring as well as investigation into important and open scientific questions in HIV pathogenesis. These goals will be met in the following three aims, which incorporate multiple clinical studies and six current mentees. SPECIFIC AIM 1: To determine virologic and immunologic dynamics during primary HIV infection by investigating: the genital tract (1A), gut associated lymphoid tissue (1B), and the neutralizing antibody response in the blood (1C). SPECIFIC AIM 2: To validate pooling methods for diagnostic purposes in resource limited settings to detect: virologic failure of antiretroviral therapy (2A) and sub-acute malaria infection in the setting of HIV infection (2B). SPECIFIC AIM 3: To use molecular epidemiologic methods to characterize HIV-1 transmission networks between San Diego and Tijuana. Taken together, this proposal will allow the mid-career applicant to continue and expand his HIV research and mentoring activities.