Developmental Psychopathology of Restrictive and Binge Eating in Childhood

描述（由申请人提供）：候选人：我是查佩尔山的北卡罗来纳州大学精神病学系进食障碍项目的研究助理教授。我接受过发育精神病理学和饮食失调方面的培训。我正在寻求儿童饮食失调，精神遗传学，纵向数据分析和蛋白质组方法学的培训。职业目标：我的最终目标是定义前驱饮食失调（饮食失调发作前出现的早期体征和症状），并开发儿童饮食失调风险的预后算法。检测前驱饮食失调的转化科学可能有可能通过早期干预改变发育轨迹来预防后期饮食失调。职业发展：我计划在四个方面培养我的技能和专业知识：1。儿童期饮食失调; 2。精神病学遗传学，包括多基因风险指数的发展; 3。纵向数据分析，包括潜在轨迹建模;以及4.前驱症状理论、方法论与合作研究。研究项目：拟议的项目利用以前从挪威母亲和儿童研究（MoBa）收集的数据来利用现有资源，MoBa是一项纵向前瞻性出生队列研究和约110 000名挪威儿童及其母亲的生物库。首先，我将绘制18个月至8岁儿童限制性饮食的发展轨迹，并测试8岁儿童限制性饮食的途径模型（例如，避免食物和情绪低估，在愤怒或焦虑时少吃）。其次，我将绘制36个月至8岁儿童暴饮暴食的发展轨迹，并测试8岁儿童暴饮暴食的途径模型（例如，在短时间内吃大量食物，并对饮食失去控制，产生无法停止进食的印象）。第三，我将研究增加神经性厌食症多基因风险指数的影响，以告知儿童限制性饮食的轨迹和途径模型，在母亲患有和没有神经性厌食症的儿童。在未来的独立应用（R 01）中，这些结果将为MoBa中有进食障碍风险的儿童的多方法直接观察提供信息，因为他们进入青春期，这是进食障碍发病风险最大的时期。工作环境：研究和培训将在挪威查佩尔山的精神病学系进行，并在挪威公共卫生研究所进行额外培训。导师制：导师团队包括首席导师、心理学家辛西娅·布利克博士和国际公认的饮食失调研究和治疗专家，以及共同导师、精神病学家、精神病遗传学首席专家帕特里克·沙利文博士。博士 Eliana Perrin是一名儿科医生，擅长于儿童中期的饮食失调。Kari North博士是一名遗传流行病学家，将提供整合遗传学和纵向数据分析和方法的专业知识。顾问Ted Reichs-Kjennerud博士是MoBa数据集和精神病遗传流行病学的精神病学家和专家。顾问Robert Hamer博士是生物统计学家和纵向建模专家。顾问戴安娜·珀金斯博士是一位精神病学家，也是北美精神分裂症前驱症状纵向研究基因组学部分的联合首席研究员。

DESCRIPTION (provided by applicant): Candidate: I am a Research Assistant Professor with the Eating Disorders Program in the Department of Psychiatry at The University of North Carolina at Chapel Hill. I have training in developmental psychopathology and eating disorders. I am seeking training in childhood deregulated eating, psychiatric genetics, longitudinal data analysis, and proteome methodology. Career Goals: My ultimate goal is to define prodromal eating disorders-early signs and symptoms that emerge before the onset of eating disorders-and develop a prognostic algorithm of eating disorder risk in children. Translational science to detect prodromal eating disorders could have the potential to prevent later eating disorders by altering developmental trajectories through early intervention. Career Development: I plan to build my skills and expertise in four areas: 1. Dysregulated eating in childhood; 2. Psychiatric genetics including the development of a polygenic risk index; 3. Longitudinal data analyses including latent trajectory modeling; and 4. Prodrome theory, methodology, and collaborative research. Research Project: The proposed project leverages existing resources by using previously collected data from the Norwegian Mother and Child Study (MoBa), a longitudinal prospective birth cohort study and biobank of ~110,000 Norwegian children and their mothers. First, I will map the developmental trajectories of restrictive eating in children from 18 months t 8 years of age and test models of pathways to 8-year-old's restrictive eating (e.g. food avoidance and emotional underrating eating less when angry or anxious). Second, I will map the developmental trajectories of binge eating in children from 36 months to 8 years of age and test models of pathways to 8-year-old's binge eating (e.g. eating large amount of food in a short period of time and experiencing loss of control over eating having the impression that one could not stop eating). Third, I will examine the impact of the addition of an anorexia nervosa polygenic risk index to inform trajectory and pathway models of children's restrictive eating in the children of mothers with and without anorexia nervosa. In future independent applications (R01s), these results will inform multi-method direct observations of the children at risk for eating disorders in MoBa as they age into adolescence, the period of greatest risk for eating disorder onset. Environment: The research and training will take place in the Department of Psychiatry at UNC Chapel Hill with additional training in the Norwegian Institute of Public Health. Mentorship: The mentorship team includes lead mentor, Dr. Cynthia Bulik, a psychologist, and internationally recognized expert in eating disorder research and treatment and co-mentor, Dr. Patrick Sullivan, a psychiatrist and leading expert in psychiatric genetics. Dr. Eliana Perrin, consultant, is a pediatrician with expertise in deregulated eating in middle childhood. Dr. Kari North, consultant, is a genetic epidemiologist and will provide expertise in integrating genetics and longitudinal data analysis and methods. Dr. Ted Reichborn-Kjennerud, consultant, is a psychiatrist and expert in the MoBa dataset and psychiatric genetic epidemiology. Dr. Robert Hamer, a consultant, is a biostatistician and expert in longitudinal modeling. Dr. Diana Perkins, consultant, is a psychiatrist and co-principal investigator of genomics component of the North American Prodrome Longitudinal Study for schizophrenia.