Dynamics of targeted gene knockdowns in A. burtoni
Dynamics of targeted gene knockdowns in A. burtoni
批准号:
8701415
负责人:
RUSSELL D FERNALD
金额:
$7.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-08-01 至 2015-07-31
关键词:
AdultAfricaAfricanAnimalsAntisense OligonucleotidesBehaviorBehavior ControlBehavioralBehavioral ModelBiological ModelsCandidate Disease GeneCichlidsCodeComplexCuesEmbryoEnvironmentFunctional RNAGene ExpressionGene Expression ProfileGene SilencingGene TargetingGenesGenomeGenomicsGoalsHumanMapsMeasuresMental DepressionMental disordersMethodsMicroRNAsModelingMolecularNeuronal PlasticityNeuronsOutcomePatternPenetrancePhenotypePhysiologicalPilot ProjectsRoleSchizophreniaSocial BehaviorSocial statusSystemTechniquesTestingTissuesToxic effectTranscriptTransgenic AnimalsTransgenic Organismsanimal datagenome sequencingin vivonovelpublic health relevanceresearch studyresponsesocialtooltranscriptomics
中文摘要
描述(由申请人提供):该项目将为一种新的行为模型系统开发基因敲除方法。我们研究的动物在行为和生理上对社会暗示做出反应,随着它们在社会地位的上升或下降而改变表型。具体地说,我们可以操纵社会系统来模仿自然环境,并识别出对社会信息做出反应的神经元。我们收集了不同的、受社会调节的表型的动物的基因表达数据,这些动物产生了可能调节社会行为的候选基因。我们将开发抑制基因表达的方法,以测试哪些基因负责特定方面的行为变化。
英文摘要
DESCRIPTION (provided by applicant): This project will develop gene knockdown methods for a novel behavioral model system. Animals we study respond to social cues behaviorally and physiologically, changing phenotype as they ascend or descend in social status. Specifically, we can manipulate the social system to mimic the natural environment and have identified neurons that respond to social information. We have collected gene expression data from animals of distinct, socially regulated phenotypes producing candidate genes that putatively regulate social behavior. We will develop methods to silence gene expression to test which genes are responsible for particular aspects of behavioral change.
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会议论文
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