Bioinformatics and Information Technologies

项目摘要（见说明）：核心L -大量复杂数据和现代计算技术正在从根本上改变科学探究和公共卫生，这些技术能够挖掘这些数据以发现模式并进行推理。艾滋病毒研究领域也不例外，许多创新发现都是通过复杂的建模和数据分析促进或验证的。传统的生物统计学服务既不是为处理大量复杂数据而设计的，这些新数据类型（例如，下一代测序数据）也不适合当前的计算生物学和信息学应用。生物信息学和信息技术（BIT）的目的是处理CFAR研究者对存储、管理、分析、解释和传播大型和复杂数据集的需求，特别是那些包含病毒和宿主分子序列的数据集。基于CFAR成员目前和预期的未来需求，在未来五年内，BIT核心将被构建为三个相互关联的单元，它们将：(1)利用加州大学圣地亚哥分校在生物信息学和计算生物学方面的世界级专业知识，为CFAR研究人员提供生物信息学支持，为CFAR研究人员收集的数据提供全面的服务和咨询；(2)提供内容管理系统、生物医学数据web服务和计算基础设施；(3)提供生物信息学和信息技术方面的培训。通过利用CFAR其他核心（如GS、PEP、流式细胞术核心）提供的尖端内部方法学研究、现代测序和生物医学技术，以及编程团队的专业软件开发和支持专业知识，BIT Core具有独特的定位，可以为CFAR成员提供这些创新服务。2012年2月，CFAR外部咨询委员会审查了我们的中心，并在他们的最终报告中指出：“BIT核心可能会为CFAR如何处理设定标准

PROJECT SUMMARY (See instructions): Core L - Scientific inquiry and public health are being fundamentally changed by immense volumes of complex data, and modern computational techniques that are able to mine these data for pattern discovery and inference. The field of HIV research is no exception, and many innovative discoveries have been facilitated or validated by sophisticated modeling and data analyses. Traditional biostatistics services are neither designed to handle gigantic volumes of complex data, nor are these new data types (e.g., next generation sequencing data) a natural fit for current computational biology and informatics applications. The purpose of the Bioinformatics and Information Technologies (BIT) is to handle CFAR investigator demand for storing, managing, analyzing, interpreting, and disseminating large and complex data sets, especially those containing viral and host molecular sequences. Based on ongoing and anticipated future needs of CFAR members, in the next five years, the BIT Core is structured as three interlinked units that will: (1) provide bioinformatics support for CFAR researchers by leveraging world-class expertise in bioinformatics and computational biology available at UCSD to offer a comprehensive spectrum of services and consultations related to computational analyses of data collected by CFAR investigators; (2) supply content management systems, web services for biomedical data, and computational infrastructure; and (3) provide training in bioinformatics and information technology. The BIT Core is uniquely positioned to provide these innovative services to CFAR members by drawing upon cutting edge in-house methodological research, modern sequencing and biomedical technologies offered by other CFAR Cores (e.g. GS, PEP, Flow Cytometry Cores), and professional software development and support expertise of its programming team. The CFAR External Advisory Committee reviewed our Center in February, 2012 and noted the following about the BIT Core in their final report: "The BIT Core is likely to set the standard for how CFARs handle next generation sequencing analysis, cohort data management and provide web presence."