A novel magnetic resonance imaging (MRI) technique to characterise white matter microstructure in the brain

脑白质（WM）细胞结构的完整性对正常信号传导至关重要，在多发性硬化症等疾病中被破坏。由于其独特的分子排列，WM微结构具有明显的磁化率特征，可以通过高场和超高场磁共振成像（MRI）检测到。本项目的目的是开发和验证一种新的方法，在高（亚体素）分辨率下用MRI绘制敏感性效应。结果将是更全面地了解MRI信号变化与WM微结构之间的关系，并改进易感图谱，从而可能导致早期诊断和更有效的治疗监测。

Integrity of the cellular architecture of brain white matter (WM) is vital to normal signal conduction and is disrupted in diseases such as multiple sclerosis. Due to their characteristic molecular arrangements, WM microstructures have distinct magnetic susceptibility characteristics that can be detected with high-field and ultra high-field magnetic resonance imaging (MRI). The objective of this project is to develop and validate a novel method of mapping susceptibility effects at high (sub-voxel) resolution with MRI. The outcomes will be a more comprehensive understanding of the relationship between changes in MRI signal and WM microarchitecture and improved susceptibility mapping that may lead to earlier diagnosis and more effective therapeutic monitoring.