Cancer Research International Training and Intervention Consortium (CRITIC)

描述（由申请人提供）：拟议的癌症联盟重点关注坦桑尼亚卡波西肉瘤相关人类疱疹病毒（KSHV）和人类乳头状瘤病毒（HPV）两种最常见的艾滋病相关癌症的两种病原性病毒媒介的传播和感染的干预。该联盟的目标是加强艾滋病恶性肿瘤研究基础设施的三个关键组成部分——病毒学、流行病学和临床护理——通过将在这些领域具有文献记载优势的伙伴联系起来。除了获得与艾滋病有关的恶性肿瘤的关键数据外，该联盟还将提供各种培训机会，以增加当地的专门知识和转让技术。总的来说，这种伙伴关系最终将导致建立技术和人员基础设施的交流

DESCRIPTION (provided by applicant): The proposed Cancer Consortium focuses on the intervention of transmission and infection by two etiologic viral agents of the two most common AIDS-associated cancers, the Kaposi's sarcoma-associated human herpes virus (KSHV) and Human Papilloma Virus (HPV) in Tanzania. The objective of the Consortium is to enhance the three critical components of AIDS malignancies research infrastructure - virology, epidemiology and clinical care - by linking partners with documented strengths in these areas. In addition to deriving critical data on AIDS-associated malignancies, the Consortium will provide diverse training opportunities to increase local expertise and transfer technology. Overall, the partnership will ultimately lead to exchanges that build the technical and personnel infrastructure necessary to perform the high-quality biomedical, behavioral, and preventative biomedical research desperately needed in Tanzania. Four specific aims will be pursued: 1) Build the consortium's research capacity through long-term molecular cancer epidemiology training opportunities, with long-term training leading to two PhDs, in epidemiology and in molecular tumor virology, MS degrees in molecular tumor virology, and MPH degrees in cancer epidemiology. 2) Strengthen existing cancer research capacity through short term technical training in the US and in-country workshops targeting researchers, clinicians, and public health personnel. 3) Develop a molecular virology research laboratory component and epidemiology/biostatistics core facilities to support molecular cancer epidemiology research projects. 4) Support the development of Tanzanian research teams and increase the research productivity through supporting two hypothesis-driven research projects in the two most prevalent AIDS-associated malignancies, KS and cervical cancer. This proposed program is unique and of high impact because it builds onto a successful ongoing Fogarty program and NCI training program in sub-Saharan Africa, expanding it into a truly cross-disciplinary research and training program with different training tracks and with in-country research projects teaming Tanzanian and U.S. researchers to conduct hypothesis-driven research on KS, cervical cancer, and their respective etiologic agents.