FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function

描述（由申请人提供）：本提案的具体目的是为美国实验生物学学会联合会（FASEB）主办的关于“免疫细胞发育和功能的分子机制”的夏季研究会议（SRC）获得部分支持。该会议最初名为“淋巴细胞和免疫系统：分子，细胞和互动机制”，自2003年夏季成立以来，每隔一年进行一次竞争性重新评估后，被FASEB选为赞助商。这次会议的特点如下。(1)会议重点强调淋巴细胞发育中基因调控的分子生物学，包括从全基因组方法中出现的新见解。(2)指导免疫受体基因突变的分子机制是一个重点，解释识别特异性的基础，也建立了远程基因组控制机制的先例。(3)该计划有意将对不同类别免疫细胞的研究并列，以便可以看到发育选择的机制和共享使用特定分子机制的更大模式。(4)许多演讲者明确关注基因网络和信号网络连接，而不是“一次一个基因”的研究，以提供生物调控的最全面的解释。(5)该计划整合了来自多个层次的科学家的演讲，从国际知名专家到初级博士后和研究生演讲者，在一个密集的，全全会程序。因此，年轻的受训者很容易接触到有经验的高级人物，他们可以欣赏年轻人的个人想法。本次会议得到了前几次会议与会者的热烈反馈，并得到了长期持续下去的有力授权。本申请将为2013年夏季的会议提供所需的支持，这是这个非常成功的系列中的第六次会议。在这个时候，当资金紧张，许多潜在的与会者，特别是初级教师，根本负担不起来，除非他们可以得到某种旅行或注册支持，无论他们的结果可能是多么令人兴奋。所要求的资金将补充FASEB提供的有限资金，以及我们可以从私营企业寻求的任何捐款。这一支持至关重要，可以支付受邀演讲者的登记费用，并为一批选定的青年科学家提供旅费 主持人

DESCRIPTION (provided by applicant): The specific aim of this proposal is to obtain partial support for a Summer Research Conference (SRC) sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of "Molecular Mechanisms of Immune Cell Development and Function". This conference, originally titled "Lymphocytes and the Immune System: Molecular, Cellular, and Interactive Mechanisms", has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are the following. (1) The meeting places strong emphasis on molecular biology of gene regulation in lymphocyte development, including new insights emerging from genome-wide approaches. (2) Molecular mechanisms guiding immune receptor gene mutagenesis are an emphasis, explaining the basis of recognition specificity and also establishing precedents for long-range genomic control mechanism. (3) The program deliberately juxtaposes research on different classes of immune cells, so that mechanisms underlying developmental choices and larger patterns of shared use of particular molecular mechanisms can both be seen. (4) Many presenters have an explicit focus on gene network and signaling network connections rather than "one gene at a time" studies, to provide the most comprehensive available explanations of biological regulation. (5) The schedule integrates presentations from scientists at many levels, from internationally renowned experts to junior postdoctoral and graduate student speakers, in an intensive, all-plenary program. As a result, young trainees have uncommonly easy access to experienced senior figures, who can gain an appreciation for the young people's individual ideas. This meeting has received enthusiastic feedback from conference attendees of the previous meetings and a strong mandate for long-term continuation. The present application would provide needed support for the conference in the summer of 2013, which is the 6th conference in this highly successful series. At this time when funding is tight, many potential attendees, especially junior faculty, simply cannot afford to come unless they can receive some kind of travel or registration support, no matter how exciting their results may be. The funds requested would supplement limited funds provided by FASEB, as well as whatever contributions we can solicit from private industry. This support is crucial to make it possible to cover the costs of registration for invited speakers and to offer travel awards for a select group of junior scientist presenters.