Creating a computerized self-administered version of Comprehensive Behavioral Int

项目摘要/摘要 此第二阶段SBIR建议在我们成功的第一阶段活动的基础上扩展，以完成开发和测试 一种创新的基于计算机的治疗-交付产品对慢性抽动障碍儿童的疗效 (CTD；包括多发性抽动症)及其家人。CTD代表了一类神经精神障碍， 发生在0.6%-3%的学龄儿童中，可能导致严重的身体、社会和心理障碍， 学业、人际功能和生活质量下降。目前，CTD还没有治愈方法， 然而，在大规模随机对照试验中，一种被称为 抽搐的综合行为干预(CBIT)被证明在没有不良副作用的情况下减少了抽搐 与药物治疗相关的效果。治疗师指导的、经经验验证的CBIT方案是可用的， 然而，绝大多数想要CBIT的人无法获得受过 实施这一干预措施。考虑到CTD儿童需要非药物治疗方案， 潜在最终用户对这种治疗的渴望，以及缺乏受过充分培训的从业者 在治疗方面，显然需要创新的传播方式。在我们最近完成的(和 成功)第一阶段项目，目前的提案合作伙伴是CBIT的两个主要开发商 与心理科技有限公司进行干预，以最终开发和测试高度可访问性和相对 便宜的计算机自助版CBIT。我们第一阶段项目的结果表明， TICHELPER原型版获得了专业人士和最终用户(儿童 CTD及其父母)关于可行性、可接受性和可用性的指标。第一阶段先导研究的结果 也表明TICHELPER对减少核心CTD症状是有效的。第一阶段的结果有力地证明了 第二阶段，在此期间，我们将全面开发和测试TicHelper的功效。这项第二阶段的提案旨在 (1)与最终用户一起使用迭代反馈过程来开发CBIT的其余核心组件 协议(即放松训练、基于功能的干预和充分发展的习惯逆转模块，以 解决核心CTD症状)到自我管理的在线形式，以及(2)比较 在一项随机对照试验中，TICHELPER被转移到基于互联网的资源(IBR)条件。 好了！

Project Summary/Abstract This Phase II SBIR proposes to expand upon our successful Phase I activities to finalize development and test the efficacy of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD; including Tourette Disorder) and their families. CTD represents a class of neuropsychiatric disorders, occurring in 0.6-3% of school-aged children that can lead to significant impairments in physical, social, academic, and interpersonal functioning and reduced quality of life. Currently, there is no cure for CTD, however in large-scale randomized controlled trials, a non-pharmacological treatment known as Comprehensive Behavioral Interventions for Tics (CBIT) was shown to reduce tics without the adverse side effects associated with pharmacotherapy. A therapist-guided, empirically validated CBIT protocol is available, however the vast majority of individuals who desire CBIT do not have access to therapists trained in the delivery of this intervention. Given the need for non-pharmacological treatment options for children with CTD, a desire for such treatments by potential end-users, and the absence of practitioners adequately trained in the treatment, there is a clear need for innovative modes of dissemination. Following our recently completed (and successful) Phase I project, the current proposal partners two of the primary developers of the CBIT intervention with PsycTech Ltd., to finalized development and test a highly accessible and relatively inexpensive computerized self-help version of CBIT. Results from our Phase I project demonstrated that a prototype version of TICHELPER received high ratings from both professionals and end-users (children with CTD and their parents) on indices of feasibility, acceptability, and usability. Results from the Phase I pilot study also show that TICHELPER was effective for reducing core CTD symptoms. Phase I results strongly justify Phase II, during which we will fully develop and test the efficacy of TicHelper. This Phase II proposal aims to (1) use an iterative feedback process with end-users to develop the remaining core components of the CBIT protocol (i.e., relaxation training, function-based intervention, and the fully developed habit reversal module to address core CTD symptoms) into a self-administered online format, and (2) to compare the efficacy of TICHELPER to an Internet-Based Resources (IBR) condition in a randomized controlled trial. !