Mentoring

该申请旨在建立unc -马拉维癌症联盟（UNC-MCC），以发展能力并开展以艾滋病毒相关癌症为重点的高影响力研究。该联盟建立在北卡罗来纳大学教堂山分校（UNC-CH）、灯塔信托基金、马拉维卫生部和马拉维大学医学院（COM）之间的长期合作基础上。这些伙伴关系为撒哈拉以南非洲的艾滋病毒护理和预防作出了国际公认的贡献。这种基础设施现在可用于治疗与艾滋病毒相关的恶性肿瘤。UNC-MCC专注于疱疹病毒相关的癌症、卡波西肉瘤（KS）和淋巴瘤。我们的联盟将由三位具有高度互补专业知识的主要研究者领导（Satish Gopal医学博士，临床研究；Sam Phiri博士，实施科学；Blossom Damania博士，病毒学）。该联盟的指导/职业发展核心（指导核心）将由来自UNC马拉维项目的Mina Hosseinipour博士和George Liomba MBBS FRCPath领导。两人都是多产的导师，在马拉维指导临床研究人员有几十年的经验。支持他们的是马拉维和UNC-CH的一个已建立的导师小组，他们已被招募在财团合作伙伴优先考虑的关键内容领域提供指导。指导核心活动将建立在现有NIH拨款的基础上，以提高人类研究能力。该中心还将利用与COM现有的合作伙伴关系，包括其研究生临床培训项目和医学院。指导核心将侧重于以下目标：(1)培养能够成功争取到专注于艾滋病毒相关恶性肿瘤的独立资助的马拉维研究人员；(2)创建一个“导师导师”方案，以培养马拉维临床医生或研究人员，他们可以作为医学学生、公共卫生学生和研究生学员的独立导师；(3)向有前途的马拉维研究人员提供至少8笔试点资助，以便为更大规模的资助申请获取初步数据，并支持与艾滋病毒相关的恶性肿瘤相关的高质量研究生论文。通过这些目标，指导核心将支持UNC-MCC在马拉维发展人力能力和基础设施的总体目标，特别是针对艾滋病毒相关癌症的研究。

This application is to establish the UNC-Malawi Cancer Consortium (UNC-MCC), to develop capacity and conduct high-impact research focused on HIV-associated cancers. The consortium builds on longstanding collaborations between the University of North Carolina at Chapel Hill (UNC-CH), Lighthouse Trust, Malawi Ministry of Health, and University of Malawi College of Medicine (COM). These partnerships have resulted in internationally recognized contributions for HIV care and prevention in sub-Saharan Africa. This infrastructure can now be leveraged for HIV-associated malignancies. UNC-MCC is focused on the herpesvirus-associated cancers, Kaposi sarcoma (KS), and lymphoma. Our consortium will be led by three principal investigators with highly complementary expertise (Satish Gopal MD, clinical research; Sam Phiri PhD, implementation science; Blossom Damania PhD, virology). The Mentoring/Career Development Core (Mentoring Core) for the consortium will be led by Mina Hosseinipour MD MPH, and George Liomba MBBS FRCPath, both from UNC Project-Malawi. Both are highly prolific mentors with decades of experience mentoring clinical investigators in Malawi. Supporting them are an established group of mentors in Malawi and at UNC-CH, who have been enlisted to provide mentorship in key content areas prioritized by consortium partners. Mentoring Core activities will build on existing NIH grants to increase human research capacity. The core will also leverage existing partnerships with COM, including its postgraduate clinical training programs and medical school. The Mentoring Core will be focused on the following aims: (1) develop Malawian investigators who successfully compete for independent funding focused on HIV-associated malignancies; (2) create a 'Mentor the Mentors' program to develop Malawian clinicians or researchers, who can serve as independent mentors to medical students, public health students, and postgraduate trainees; and (3) provide at least eight pilot grants to promising Malawian investigators to obtain preliminary data for larger grant applications, and support high-quality postgraduate dissertations related to HIV-associated malignancies. Through these aims, Mentoring Core will support the overall UNC-MCC aim to develop human capacity and infrastructure in Malawi, specifically for HIV-associated cancer research..