UAB Diabetes Research Center

描述（由申请人提供）：该提案将继续2008年在UAB首次建立的DRTC的进展，并向DRC过渡。该中心的直接目标是促进卓越的糖尿病研究。在过去的4年里，刚果民主共和国激发了UAB研究社区对糖尿病的研究，使成员从115人增加到159人，校外研究经费增加了32.5%。通过这些努力，中心最终致力于降低糖尿病的发病率/死亡率，并为糖尿病研究的培训和职业发展提供一个良好的环境。我们的具体目标是：1。通过赞助研究人员明确要求的核心设施，促进和加强糖尿病研究。五个研究核心涵盖了广泛的翻译谱：生物分析氧化还原生物学，胰岛细胞生物学，动物生理学，人类生物学和干预与翻译核心。通过试点和可行性资助计划加强糖尿病研究，该计划将强调创新，翻译和高度有前途的初级研究人员的职业发展。3. 赞助一个综合的浓缩计划，为优秀的多学科研究者基地提供一个有凝聚力的环境，这将加强学习、合作、合作和创新。4. 通过响应调查人员不断变化的需求并通过推动新想法和调查路线的领导，在我们最初4年取得的进展的基础上再接再厉。5. 强调研究、培训和推广，以满足我们学员的需求，为我们的患者取得更好的结果，减轻我们社区和国家的糖尿病高负担。6. 利用UAB领导层的决心，实质性的机构承诺，以及来自我们社区的慷慨慈善事业，进一步推动在深南心脏地区卓越糖尿病研究卓越中心的发展。我们的DRC位于美国糖尿病发病率最高的社区，并围绕共同的主题联合研究人员在心脏代谢疾病的背景下研究糖尿病。

DESCRIPTION (provided by applicant): This proposal will continue the progress of the DRTC, first established at UAB in 2008, and the transition to a DRC. The immediate goal of the center is to promote excellence in diabetes research. Over the past 4 years, the DRC has galvanized the UAB research community around the study of diabetes resulting in an increase in membership from 115 to 159, and a 32.5% increase in extramural research funding. Through these efforts, the center ultimately endeavors to decrease diabetes morbidity/mortality, and to provide an outstanding environment for training and career development in diabetes research. Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base. The five research cores cover a broad translational spectrum: Bioanalytical REDOX Biology, Islet Cell Biology, Animal Physiology, Human Biology, and Interventions & Translation Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Build upon the progress achieved over our first 4 years by responding to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation. 5. Emphasize research, training, and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 6. Leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. Our DRC is located in a community with the highest rates of diabetes in the US, and unites investigators around common themes to study diabetes in the context of cardiometabolic disease.