Training to Improve Cardiovascular Therapies

项目描述(由申请者提供)：该项目的目标是培养有前途的新科学家，使他们掌握心血管疾病的机制、实验策略以及开发新的分子疗法所必需的技术。该项目的主题是多学科综合项目中的信号转导，重点关注心血管发育、蛋白质组学、心脏干细胞和再生医学中的分子事件，以及心血管疾病的分子基础。未来几十年，我们对涉及心血管疾病的分子的结构和功能的了解将取得快速进展，并有望成功地将这些见解应用于开发新的治疗方法和预防心血管疾病。这种进步将需要训练有素、精力充沛、多产的科学家，他们有能力理解和操纵生理环境中的分子事件。这些都是我们打算通过本培训计划的博士后和博士后综合部分培养的个人类型。36名符合导师资格的教职员工是根据他们对心血管疾病的研究兴趣、积极的NIH研究支持、持续的合作、成功的培训和指导经验以及对博士前和博士后培训的承诺来挑选的。方案主任和联席主任由一个方案指导委员会和一个由心血管生物学领域杰出专家组成的外部咨询委员会提供协助。培训计划的关键组成部分包括导师研究经验、提供心血管疾病广泛视角的必修教学课程、必备培训和负责任的研究指导、选修课程、心血管杂志俱乐部、研讨会、在地区和国家会议上的演讲以及专业发展活动。心血管杂志俱乐部、研讨会、工作坊、学生研究日和一年一度的心血管静修为所有学员提供了一个框架，让他们在培训期间进行互动、合作和合作。综合的多年评估计划用来衡量达到方案目标和目的的程度。我们的目标是培养出对心血管功能障碍有广泛洞察力的杰出研究人员，他们对了解这些疾病和开发心血管疾病的治疗方法做出了重大贡献。

DESCRIPTION (provided by applicant): The program objective is to train promising new scientists in mechanisms of cardiovascular diseases, experimental strategies and technologies necessary for development of novel molecular therapeutics. The theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the successful application of these insights into the development of novel treatments and prevention of cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this training program. The 36 mentor-eligible faculty members were selected on the basis of their research interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program Director and Co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of cardiovascular biology. Key components of the training program are the mentor research experience, required didactic courses providing a broad perspective of cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular journal club, seminars, presentations at regional and national conferences, and professional development activities. The cardiovascular journal club, seminars, workshops, student research day, and annual cardiovascular retreat provide a framework for all trainees to interact, collaborate, and work together during their training experience. An integrative, multi-year evaluation plan is used to measure the extent to which the program goals and objectives are met. Our aim is to produce outstanding investigators with a broad insight into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and development of therapies for cardiovascular diseases.