Computational and Mathematical Modeling of Biomedical Systems

描述(由申请者提供)：该计划通过博士前水平的跨学科培训，为科学家在具有重要医学意义的生物系统的计算和数学建模方面的研究生涯做准备。亚利桑那大学以其完善的跨学科研究生课程体系和跨部门合作的传统而闻名，为此类培训提供了非常合适的环境。18名培训教师和3名副教授在多个系和跨学科研究生项目中任职，在五个广泛的领域提供优势：生物信息学；分子动力学；细胞过程；生理学和病理生理学；生物统计学和随机过程。学生来自数学和生命科学的多个研究生项目，包括应用数学跨学科研究生项目。在大多数情况下，学生从研究生培训的第二年或第三年开始，就会从这个项目中获得两年的支持。受训者追求他们自己研究生课程的课程要求，此外，还参加数学建模和生物信息学的研究生课程，这些课程是根据受训者的需求量身定做的，并考虑到他们不同的科学背景。所有学员都参加每周一次的生物数学讨论会，该讨论会已经连续举办了十五年以上。本次座谈会包括学生、教师和来访演讲者的演讲，并促进主要具有数学或计算背景的学员和教师与具有较强生物培训背景的学员和教师之间的对话。受训者在导师的指导下进行博士研究，他们的研究无论是理论上的还是实验上的，都强调将理论方法应用于生物医学问题。在适当的情况下，任命一名联合顾问，以补充主要顾问的专业知识。参与该计划的学员不仅接受相关领域的研究培训，而且同样重要的是培养跨越传统学科界限的沟通和合作能力，以及与具有互补专业知识的研究人员合作的能力。在生物医学科学的许多领域，迫切需要具有这种技能的研究人员，在这些领域，需要复杂的理论方法才能取得进一步的进展。

DESCRIPTION (provided by applicant): This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral level. Noted for its well-established system f interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries, the University of Arizona provides a highly suitable environment for such training. Eighteen training faculty and three associate faculty with appointments in multiple departments and interdisciplinary graduate programs provide strength in five broad areas: bioinformatics; molecular dynamics; cellular processes; physiology and pathophysiology; biostatistics and stochastic processes. Students are drawn from multiple graduate programs in mathematical and life sciences, including the interdisciplinary Graduate Program in Applied Mathematics. In most cases, students receive two years of support from this program, starting in their second or third year of graduate training. Trainees pursue the coursework requirements of their own graduate programs and, in addition, take graduate courses in mathematical modeling and in bioinformatics, which are tailored to the trainees' needs and take into account their diverse scientific backgrounds. All trainees take part in a weekly biomathematics colloquium that has been running continuously for more than fifteen years. This colloquium includes presentations by students, faculty and visiting speakers, and promotes dialog between trainees and faculty with primarily mathematical or computational backgrounds and those with strong biological training. Trainees carry out their doctoral research with advisors whose research, whether theoretical or experimental, emphasizes application of theoretical approaches to biomedical problems. Where appropriate, a co-advisor is appointed to provide complementary expertise to that of the primary advisor. Trainees participating in this program not only receive research training in relevant areas, but, equally importantly, develop the ability to communicate and collaborate across traditional disciplinary boundaries and to work with researchers with complementary expertise. Researchers with such skills are critically needed in many areas of biomedical science in which sophisticated theoretical approaches are necessary in order to achieve further progress.