Mortality in a community sample of adults with arthritis

描述（由申请人提供）：约翰斯顿县骨关节炎（JoCo OA）项目：关节炎和残疾（u01dp003206 -01 -由CDC资助）的辅助提案的目标是在当前随访期间为参与者创建一个增强的生命状态、日期和死亡原因的存储库，并检查膝关节和/或髋关节OA对非西班牙裔非洲裔美国人（AA）和高加索男性和女性死亡率的贡献。本研究旨在涵盖OA过程的多个方面，从生物医学到社会心理，从临床前到残疾。在该队列中，通过20至25年的观察和多个时间点的广泛OA和慢性病数据来检查死亡率，为以其他研究无法做到的方式回答这些问题提供了绝佳的机会，此外，还增强了母项目。目标将通过以下三个具体目标和第四个探索性目标来实现：1)创建增强的重要状态数据存储库

DESCRIPTION (provided by applicant): The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with u to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.