IGF::OT::IGF BLSA

巴尔的摩老龄化纵向研究（BLSA）由NIA校内研究项目的研究人员进行。BLSA是美国历史最悠久的人类衰老科学研究。超过1，250名男性和女性，年龄从20岁到90岁不等，是这项研究的积极参与者，超过3000名参与者。自1958年成立以来，BLSA不仅在正常衰老过程中产生了许多发现，而且还将疾病的影响与正常衰老过程分开。最近，BLSA正在收集数据，探索导致身体和认知功能随年龄增长而下降的多因素途径。 2002-2003年，NIA的研究人员为BLSA的科学议程制定了一个新的框架。虽然这项研究将保留其许多研究目标和目的，但研究人员计划将重点放在未来招募成功的老年人，或者那些75岁时几乎没有与年龄相关的疾病或残疾的人。这将使该研究能够更深入地调查预测健康老龄化和整个生命周期健康相关结果的因素，以确定成功适应老龄化的策略，并制定有关可能干预目标的假设，这些干预目标可能会积极影响特定的衰老表型并预防年龄相关疾病。此外，BLSA研究人员正在努力促进横截面和纵向分析，这将增加我们对各种参数的变化如何影响衰老，年龄相关疾病以及虚弱和残疾发展的理解。NIA研究人员还进行小型，重点突出和深入的临床研究，旨在测试在BLSA背景下开发的一些假设，并使用转化研究部分促进其临床翻译。

The Baltimore Longitudinal Study on Aging (BLSA) is conducted by investigators in the NIA Intramural Research Program. The BLSA is America's longest-running scientific study of human aging. More than 1,250 men and women, ranging in age from the twenties to the nineties, are active participants in this study from more of 3000 that were enrolled. Since its inception in 1958, the BLSA has generated numerous findings not only on the normal course of aging, but also disentangling the effects of disease from the normal aging process. More recently, the BLSA is collecting data that explore the multifactorial pathways that lead to decline of physical and cognitive function with aging. In 2002-2003 NIA investigators produced a new framework for the BLSA¿s scientific agenda. While the study will retain many of its research goals and objectives, the investigators plan to place a strong emphasis on future recruitment of ¿successful agers,¿ or those who at age 75 have few, if any, age-associated diseases or disabilities. This will permit the study to more intensely investigate factors that predict healthy aging and health-related outcomes across the life-span, to identify strategies for successful adaptation to aging, and to develop hypotheses concerning possible targets for intervention that may positively affect specific aging phenotypes and prevent age-related diseases. In addition, BLSA investigators are working to facilitate cross-sectional and longitudinal analyses that will increase our understanding of how changes in various parameters affect aging, age-related disease, and the development of frailty and disability. NIA investigators also conduct small, focused and in depth clinical studies aimed at testing some of the hypotheses developed in the context of the BLSA, and facilitate their clinical translation using the Translational Research Section.