Predictors of cognitive aging across the lifecourse

描述（由申请人提供）：本提案请求NIA继续资助Kristine Yaffe博士获得面向患者研究（K24）的职业中期研究者奖。K24续期申请的主要目的有三个：1)开展严格的基于患者的研究，以确定跨生命周期的认知衰老和脑结构完整性的预测因素。2)将申请人的研究作为指导以患者为导向的认知衰老流行病学研究人员的平台；3)使申请人能够追求新的研究方向，并继续支持其发展成为国际公认的对认知衰老感兴趣的各学科学员的导师。在K24奖提供支持的前5年里，Yaffe博士既是一位非常富有成效的导师，也是一位独立资助的研究者。在此期间，她获得了8项以患者为导向的研究资助（3项r01, 2项来自美国国立卫生研究院的项目核心项目，一项来自阿尔茨海默氏症协会的研究者发起的研究资助，一项国防部资助和一项美国卫生基金会资助）。在最初的K24项目期间（2007年至2012年），Yaffe博士担任各种学科和各级培训的19名学员的主要或次要导师。Yaffe博士的长期目标是成为老龄化研究的国际领导者，为我们对认知障碍的治疗和预防的理解和方法做出重大贡献，并指导对认知衰老流行病学感兴趣的“下一代”研究人员。这个一次性的职业中期发展奖励将帮助她实现这些目标。

DESCRIPTION (provided by applicant): This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient- Oriented Research (K24) to Dr. Kristine Yaffe. The overarching aims of this K24 renewal application are three-fold: 1) To perform rigorous patient-based research studies in a new direction aimed at the identification of the predictors of cognitive aging and structural brain integrity across the lifecourse among biracial adults, 2) To use the applicant's research as a platform for the mentorship of patient-oriented researchers in the epidemiology of cognitive aging and 3) To enable the applicant to pursue new research directions and to continue to support her development as an internationally recognized mentor for trainees from a wide range of disciplines interested in cognitive aging. During the first 5 years of support provided by the K24 award, Dr. Yaffe has been both a very productive mentor and independently funded investigator. During this period, she has obtained eight patient-oriented research grants (3 R01s, 2 Project Cores on Program Projects from NIH, an Investigator-Initiated Research Grant from the Alzheimer's Association, a Department of Defense grant and an American Health Foundation grant). Over the initial K24 project period from 2007 to 2012, Dr. Yaffe has served as primary or secondary mentor to 19 trainees in a wide range of disciplines and at various levels of training. Dr. Yaffe's long-term goals are to become an international leader in aging research, to contribute substantially to our understanding and approaches to the treatment and prevention of cognitive impairment and to mentor the "next generation" of investigators interested in the epidemiology of cognitive aging. This one-time renewal of a mid-career development award will help her to reach these goals.