Investigating the role of the NR4A nuclear receptor family in melanocyte function and tumorigenesis

红头发和白皙皮肤的人患黑色素瘤和非黑色素瘤皮肤癌的风险要大得多。了解MC1R和NR4As等基因与皮肤功能（如晒黑和保护皮肤免受紫外线伤害）的关系，将有助于更深入地了解黑色素瘤的易感性和进展。此外，了解异常NR4A调控在黑色素瘤形成中的作用将有助于确定新的治疗靶点。

Individuals with red hair and fair skin have a considerably greater risk of developing melanoma and non-melanoma skin cancer. Understanding the relationship that genes such as MC1R and NR4As have to skin functions such as tanning and protection from UV damage, will provide a greater insight into melanoma susceptibility and progression. Furthermore, understanding the role that abnormal NR4A regulation plays in melanoma formation will aid in the identification of new therapeutic targets.