Investigating the role of pigmentation pathway genes in moliness and melanoma risk

黑色素瘤是澳大利亚死亡的一个重要原因，而我们在高日照地理区域的色素沉着通常较浅，这是一个主要因素。我们的研究越来越多地指出，某些色素沉着基因除了通过色素沉着产生风险外，还对癌症风险产生直接的生化影响。了解决定皮肤、头发和眼睛颜色的基因是如何改变患上黄褐斑和黑色素瘤的风险的，对公共卫生预防计划很重要。

Melanoma is an important cause of death in Australia and our generally light pigmentation in a geographical area of high sun exposure is a major factor in this. Our research increasingly points to certain pigmentation genes having a direct biochemical influence on cancer risk in addition to their risk via pigmentation. Understanding how the genes that deternine skin, hair and eye colour act to modify moliness and melanoma risk is important for public health prevention schemes.