The Seventh International Mdm2 Workshop

描述（由申请人提供）：p53蛋白已被充分表征为在人类癌症中发挥肿瘤抑制作用。事实上，大多数人类肿瘤在TP53基因中具有持续的错义突变。Mdm 2是p53的负调节因子，其已显示通过直接结合抑制p53的转录活性以及充当E3泛素连接酶以靶向p53进行降解来起作用。与这些发现一致，Mdm 2也被认为在人类肿瘤中发挥作用，在多种癌症中观察到其过表达或基因扩增。每两年举办一次p53研讨会，汇集p53领域的最新研究报告，促进试剂的合作和交流。2010年，第15届国际p53研讨会在宾夕法尼亚州费城举行。12年前，组织了一个补充性的Mdm2研讨会，与p53会议隔年举行。第七次此类讲习班将于2013年8月在英国剑桥举行。会议由Karen Vousden博士（Beatson研究所）和Alan Fersht博士（剑桥大学）共同组织。会议地点在联合王国的剑桥大学。在这项申请中，要求提供资金，以支持三个重要的具体目标。第一个目标是促进研究生和博士后研究人员参加第六届国际MDM2研讨会，并提高他们与该领域领导人互动的能力。第二个目标是确保妇女和代表人数不足的少数群体作为特邀发言人出席和参与讲习班。这将通过两名应邀发言者的参与来实现，他们都是妇女和代表人数不足的少数群体。第三个目标是提高研究生、博士后研究人员和来自妇女和少数民族等代表性不足群体的早期调查人员的出勤率和参与度。这三个目标的目标将在很大程度上通过明智地使用旅行奖来实现。国际MDM2研讨会仍然是一个独特的场所，MDM2研究领域的研究人员可以聚集在一起分享最新的发现，促进合作，并加强试剂的交流。这通过确保Mdm 2研究人员了解这一重要领域的最新研究来刺激科学研究。这样做可以避免重复努力，可以分享陷阱，并可以尽快发展该领域的知识。

DESCRIPTION (provided by applicant): The p53 protein has been well-characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been implicated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. In 2010, the 15th International p53 Workshop was held in Philadelphia, PA. Twelve years ago, a complementing Mdm2 Workshop was organized to be held in alternating years with the p53 conference. The seventh such workshop is to be held in Cambridge, UK in August, 2013. The meeting is being co-organized by Drs. Karen Vousden (Beatson Institute) and Alan Fersht (University of Cambridge). The site of the conference is at the University of Cambridge in the United Kingdom. In this application, funds are being requested to support three important specific aims. The first aim is to facilitate the attendance o graduate students and postdoctoral researchers at the Sixth International Mdm2 Workshop and enhance their ability to interact with leaders in the field. The second aim is to ensure the attendance and participation of women and underrepresented minorities as invited speakers at the Workshop. This will be accomplished by the participation of two invited speakers who are both women and underrepresented minorities. The third aim is to enhance the attendance and participation of graduate students, postdoctoral researchers, and early-stage investigators who are from underrepresented groups including women and minorities. The goals of the three aims will largely be accomplished through the judicious use of travel awards. The International Mdm2 Workshop continues to be a unique venue in which researchers in the field of Mdm2 research can come together to share recent findings, facilitate collaborations, and enhance exchange of reagents. This stimulates scientific research by ensuring that Mdm2 investigators are aware of the most current research in this significant area. In so doing, duplicate efforts can be avoided, pitfalls can be shared, and knowledge in the field can move forward as rapidly as possible.