Training in Advanced Heart Disease Research

描述（由申请人提供）：雪松西奈心脏研究所（CSHI）正在为其高级心脏病研究培训计划申请新的机构培训补助金。拟议的培训计划的目标是为六名博士后研究员（每年3名x 2年）提供基础生物医学和转化研究方面的优秀团队指导培训，以便为他们提供必要的技能，以发展心血管科学的独立和富有成效的学术事业。我们力求确保我们所有的学员，无论是博士，医学博士还是医学博士/博士，都能深入了解心血管医学临床相关问题的基础科学，以及对严格的研究设计，适当的方法学和基础和临床研究的专家技术执行的全面理解。这不仅为临床研究人员提供了正确测试基础科学水平假设所需的技能，而且还为基础科学家提供了有关疾病临床方面的信息，以刺激实验室中临床相关的最先进研究。CSHI的研究重点包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、心血管成像、妇女健康和遗传学。该培训计划利用雪松-西奈医疗中心（CSMC）的独特优势，CSMC是密西西比以西最大的私立教学医院，长期致力于转化研究和服务当地社区。CSHI于2007年在CSMC成立，并迅速发展。它现在拥有世界上最大的成人心脏移植计划，进行了NIH资助的心脏源性干细胞治疗的首次人体试验，并吸引了许多NIH资助的基础和翻译研究人员。其中一些在其他CSMC单位，其中包括再生医学研究所，生物医学成像研究所，医学遗传学研究所，以及生理学的加州大学洛杉矶分校部门共享联合任命。受训人员在重点调查领域获得密集的研究经验，并通过正式课程进行补充，包括基础和临床研讨会，赠款和手稿写作指导，公开演讲，生物统计学和伦理学。CSMC生物医学科学系，CSMC临床学者计划和多校区NIH CTSA支持的转化科学研究所中心（CTSI，包括CSMC，UCLA，Harbor-UCLA和Charles Drew University）提供了几门课程。CTSI为我们的学员提供了获得项目种子基金的特权，临床研究设计的额外课程，以及从实验室到床边到社区进行整个研究的工具。总之，我们设计了一个计划，在支持转化研究和临床卓越的环境中提供心血管科学关键领域的深入培训。我们将积极招募具有多元化和代表性不足背景的优秀候选人，以填补该培训计划的六个职位（第一年三个）。

DESCRIPTION (provided by applicant): The Cedars-Sinai Heart Institute (CSHI) is applying for a new Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the proposed Training Program is to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years) in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all of our trainees, be they PhDs, MDs or MD/PhDs, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators wih the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of- the-art investigations in the laboratory. Areas of research focus at the CSHI include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, and Genetics. The Training Program takes advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI was established at CSMC in 2007 and has grown rapidly. It is now houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Medical Genetics Institute, as well as the UCLA Department of Physiology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the CSMC Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence. We will actively recruit outstanding candidates with diverse and underrepresented backgrounds to fill the six positions (three the first year) in this training program.