4D Nucleome Network Data Coordination and Integration Center

描述(由申请人提供)：4D核组(4DN)数据协调和集成中心(DCIC)的目标是收集、存储、管理、显示和分析在4DN网络中生成的数据。我们组建了一支在染色质相互作用数据分析、图像处理和三维数据可视化、基因组和表观数据综合分析、数据门户开发、大规模计算以及安全灵活的云技术开发方面具有良好记录的研究团队。在目标1中，我们将为来自4DN数据生产组的数据和元数据开发高效的提交管道。我们将与生产小组一起确定数据/元数据要求和质量指标，并确保及时向更广泛的科学界提供高质量、经过良好注释的数据。在目标2中，我们将为广大科学界开发一个用户友好的数据门户。该门户将提供 易于导航的访问原始和中间数据文件的界面，允许通过API进行编程访问，并将结合DCIC以及其他网络成员开发的新型分析和可视化工具。为了提高计算和存储的可扩展性和成本效益，将大力开发和部署基于云的技术。我们将举办教程和讲习班，为外部调查人员使用4DN数据和工具提供便利。在目标3中，我们将协调和协助进行多种数据类型的综合分析。这些工作将使用序列和图像数据来检查高阶染色质组织中的关键问题，这里开发的工具和算法将被合并到数据门户中，供其他研究人员使用。这三个目标将确保4DN产生的数据将对科学界产生最大影响。

DESCRIPTION (provided by applicant): The goals of the 4D Nucleome (4DN) Data Coordination and Integration Center (DCIC) are to collect, store, curate, display, and analyze data generated in the 4DN Network. We have assembled a team of investigators with a strong track record in analysis of chromatin interaction data, image processing and three-dimensional data visualization, integrative analysis of genomic and epigenomic data, data portal development, large-scale computing, and development of secure and flexible cloud technologies. In Aim 1, we will develop efficient submission pipelines for data and metadata from 4DN data production groups. We will define data/metadata requirements and quality metrics in conjunction with the production groups and ensure that high-quality, well- annotated data become available to the wider scientific community in a timely manner. In Aim 2, we will develop a user-friendly data portal for the broad scientific community. This portal will provide an easy-to-navigate interface for accessing raw and intermediate data files, allow for programmatic access via APIs, and will incorporate novel analysis and visualization tools developed by DCIC as well as other Network members. For computing and storage scalability and cost-effectiveness, significant efforts will be devoted to development and deployment of cloud-based technology. We will conduct tutorials and workshops to facilitate the use of 4DN data and tools by external investigators. In Aim 3, we will coordinate and assist in conducting integrative analysis of the multiple data types. These efforts will examine key questions in higher-order chromatin organization using both sequence and image data, and the tools and algorithms developed here will be incorporated into the data portal for use by other investigators. These three aims will ensure that the data generated in 4DN will have maximal impact for the scientific community.