Training In Drug Abuse and Brain Imaging

描述(由申请人提供)：随着多模式神经成像的广度和深度迅速扩大，有必要培训个人如何使用该技术更好地检测、理解、开发新药、跟踪和预防药物滥用。先进的MRI、PET、EEG和近红外光谱(NIRS)技术可以用来探索药物滥用和依赖的神经生物学基础。这是一项继续T32机构博士后培训计划的建议，以满足该领域的重要培训需求。这一培训计划的主要内容包括：两个地点(麦克莱恩医院和MGH)；从基础科学到临床治疗单位的多个科室参与；提供几种成像方式的培训，包括MR、PET、EEG、NIRS；临床和临床前培训机会，以及综合的翻译研究机会；NIH资助的丰富项目，以支持受训者的研究；一组在过去9年中共同工作的经验丰富的导师；可选择四个明确的培训轨道，包括：1)技术与仪器，2)临床-基础，3)临床-治疗和4)翻译；精心设计的2-3年培训计划，包括课程作业、负责任的研究指导、实验室轮换、论文和补助金撰写经验以及独立研究；学员毕业后获得独立资助的非常成功的记录；学员出版物的成功率；以及对项目的广泛机构支持，这从我们的3T和4T临床扫描仪的重大升级和9.4T动物扫描仪的增加就是明证。在过去的9年里，我们开发和维护了一个综合的、多学科的药物滥用和脑成像培训计划(DABITP)，目前支持4个博士后时段；我们建议将受训人员的数量增加到6个，因为该计划一直是满员的，我们已经扩大到包括Martinos生物医学成像中心(在MGH)，该中心为该计划和McLean医院的四个新的培训实验室提供综合的MR-PET成像培训。脑成像和精神药理学的教学培训与各种非常成功的研究实验室的实际应用相结合，为我们的受训人员提供了在他们开始下一个十年对上瘾的大脑进行研究时利用广泛的脑成像技术的技能。

DESCRIPTION (provided by applicant): As the breadth and depth of multimodal neuroimaging rapidly expands, there is an important need to train individuals on how use the technology to better detect, understand, develop new medications, track and prevent drug abuse. Sophisticated MRI, PET, EEG and Near Infrared Spectroscopy (NIRS) techniques can be used to explore the neurobiological bases of drug abuse and dependence. This is a proposal to continue a T32 Institutional postdoctoral Training Program to fill an important training need in the field. The key elements of this Training Program include: two locations (McLean Hospital and MGH); participation by multiple departments from basic science to clinical treatment units; availability of training in several imaging modalities including MR, PET, EEG, NIRS; clinical and preclinical training opportunities with integrated translational research opportunities; rich breadh of NIH funded projects to support the trainees' research; group of well-seasoned mentors who have been working together for the past 9 years of this program; option of four well-defined training tracks including: 1) Technology & Instrumentation, 2) Clinical-Basic, 3) Clinical-Treatment and 4) Translational; well-designed 2-3 year training plans that integrate coursework, responsible conduct of research, lab rotations, paper & grant writing experience and independent research; very successful track record of trainees' securing independent funding upon graduation from the program; successful rate of trainee publications; and extensive institutional support for the program as evidenced by significant upgrades to our 3T and 4T clinical scanners and the addition of a 9.4T animal scanner. Over the past 9 years we have developed and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots; we propose to increase the number of trainees to six slots because the program is consistently full and we have expanded to include the Martinos Center for Biomedical Imaging (at MGH), which brings combined MR-PET imaging training to the program and four new training laboratories at McLean Hospital. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on the addicted brain.