East Carolina University Bariatric Surgery Clinical Center

实验室的构思是为了解决减肥手术和肥胖者新陈代谢中的重要问题 病态肥胖。实验室旨在探索患者特征、临床条件、血清学之间的关系 以及遗传标记、护理过程以及临床、心理社会和健康经济结果。这个 实验室在前5年的主要成就是定义了勘探领域，确定了 适当的指标和在实验室注册5105名参与者可获得99%的重要状态数据，截止日期为30 手术后几天。此外，已经招募了1947名实验2的参与者，收集了91%的数据 随访6个月。 实验室的扩展将建立在位于6个临床站点的10个临床站点的严谨研究基础设施上 代表多个护理服务系统和患者群体的临床中心。实验室招收患者 来自6家学术医院和4家社区医院，由33名外科医生进行手术。这些网站有 创建了一个具有相当多样化的重要患者特征的队列。实验室包括21%的男性 (各网站的范围为16%至32%)，9%的黑人/非裔美国人(范围为0%至24%)，7%的西班牙裔(范围为1% 到16%)，10%60岁以上(5%-18%)，10%体重指数60+kg/m2(6%到27%)。这些功能 已经与短期和长期结果联系在一起，代表着尚未 特征充分，因为它们在大多数单中心队列中很少出现。重要的是， 不同地点的多样性更有可能代表美国的减肥手术人群 可能来自任何单独的站点。 相关性(请参阅说明)： 与单中心研究相比，多中心实验室联盟的关键科学优势包括： 1)在可比或更短的时间内招募更多患者的能力和2)A 研究基础设施具有严格的数据收集实践、高水平的数据准确性和 完整性、严谨的后续行动，以及明确定义的数据元素的全面数据库。

LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site. RELEVANCE (See Instructions): Critical scientific advantages of the multi-center LABS consortium compared to single-center studies include: 1) The ability to recruit a larger number of patients, in a comparable, or shorter, period of time and 2) A research infrastructure with rigorous data collection practices, high levels of data accuracy and completeness, rigorous follow-up, and a comprehensive database of clearly defined data elements.