Investigation of the Molecular Basis of Frailty and Development of Frailty Biomarkers in a Novel Mouse Ageing Model

虚弱是一种极易受到不利健康后果影响的状态，虚弱的患病率随着年龄的增长而增加。人们对虚弱的原因知之甚少，也没有被广泛接受的有效方法来确定一个人是否虚弱。该项目将测试虚弱的血液标志物，这将允许优化老年虚弱者的治疗，并使用虚弱的小鼠模型来了解更多关于虚弱发展的原因。

Frailty is a state of high vulnerability for adverse health outcomes, and the prevalence of frailty increases with increasing age. There is very little known about why frailty develops, and there is also no widely accepted, efficient method of determining if someone is frail. This project will test blood markers for frailty, that will allow for optimization of treatment for older frail people and use mouse models of frailty to learn more about why frailty develops.