Pilot/Exploratory Studies Core (PESC)

尽管在心血管疾病、肺部疾病、痴呆症和癌症方面的研究支出， 在身体症状、心理困扰、护理、家庭等方面的研究投入相对较少， 以及患有严重疾病的老年人的社会需求。在这份OAIC续期申请中，我们建议 试点和探索性研究核心(PESC)，建立在我们的西奈山OAIC 2010-14经验的基础上，将 实现以下目标：1)支持试点和探索性研究，以a)审查 疼痛和其他令人痛苦的症状导致独立、功能和残疾；b)制定干预措施 针对老年人的疼痛和其他痛苦症状、生活质量、功能和独立性 患有严重和慢性病的老年人；以及c)对患有严重疾病的老年人的护理进行研究的先进方法 使用非随机化设计和疾病指数队列，而不是死者；2)支持 通过提供一种机制来获得有指导的、动手的研究培训和 开发老龄化和姑息治疗的初步数据，这将导致更大规模的联邦或 基金会资助的研究项目和职业发展奖侧重于改善护理和 促进患有严重疾病的老年人独立；3)支持高级和中级教职员工 A)开展姑息治疗和老龄化方面的研究，并正在开展新的研究项目， 试点数据；b)年轻人群中的姑息治疗研究，以及谁愿意扩大或转移他们的 对老龄化的研究；或c)与姑息治疗无关的衰老研究，他们希望重新调整工作重点，以适应 在伊斯兰会议组织的主题内；和4)促进来自不同学科的研究人员之间的合作研究， 专业和机构。拟议的PESC将通过以下方式实现这些目标：1)征求和协助 开展开展工作的审查处内外调查人员开展的试点研究 与其重点相关；2)提供审查和选择支持调查员的项目的机制 职业发展；以及3)监测研究进展并协助调查人员发展 从他们的项目中独立资助研究。我们将资助标准的试点应用程序(规模：50-75,000美元； 期限：1-2年)每年到期一次或两次，以及小规模试点申请(规模：10-25K美元；期限：1年) 在滚动的基础上，允许快速生成试点数据和快速对RFA作出反应。西奈山 老年医学、姑息治疗、卫生政策和老年精神病学的教员和项目，以及它与 NPCRC、Bronx VA、犹太之家和护士服务访问调查员将是一个丰富的潜力来源 PESC调查人员将在最初的飞行员结束后开发新的飞行员。

Despite research spending on cardiovascular disease, pulmonary disease, dementia, and cancer, there has been relatively little spending on studies of the physical symptoms, psychological distress, and care, family, and social needs of older persons living with serious illness. In this OAIC renewal application we propose a Pilot and Exploratory Studies Core (PESC) that builds upon our Mount Sinai OAIC 2010-14 experience that will accomplish the following aims: 1) support pilot and exploratory studies that will a) examine the relationship of pain and other distressing symptoms to independence, function, and disability; b) develop interventions directed at pain and other distressing symptoms, quality of life, function, and independence for older adults with serious and chronic illness; and c) advance methods for the study of care of older adults with serious illness using non-randomized designs and illness-indexed cohorts as opposed to decedents; 2) support the development of junior faculty by providing a mechanism to obtain mentored, hands-on research training and develop preliminary data in aging and palliative care that will lead to the development of larger federal or foundation funded research projects and career development awards focused on improving care and promoting independence for older adults with serious illness; 3) support senior and mid-level faculty who are conducting a) studies in palliative care and aging and who are embarking on new research projects requiring pilot data; b) palliative care research in younger populations and who would like to expand or shift their research into aging; or c) aging research unrelated to palliative care who would like to refocus their work to fit within the OAIC theme; and 4) foster collaborative research among investigators from different disciplines, specialties, and institutions. The proposed PESC will accomplish these aims by: 1) soliciting and assisting in the development of pilot studies from investigators within and outside the OAIC who are conducting work relevant to its focus; 2) providing a mechanism for review and selection of projects that will support investigator career development; and 3) monitoring the progress of studies and assisting investigators in developing independently funded research from their projects. We will fund standard pilot applications (size: $50-75,000; duration: 1-2 years) due once or twice yearly, and small pilot applications (size: $10-$25K; duration: 1 year) due on a rolling basis, to permit rapid generation of pilot data and rapid response to RFAs. Mount Sinai's faculty and programs in geriatrics, palliative care, health policy, and geropsychiatry, and its affiliations with NPCRC, Bronx VA, Jewish Home, and Visiting Nurse Service investigators, will be a rich source of potential PESC investigators to develop new pilots once initial pilots end.