EB2015: DEBRA International Symposium on Epidermolysis Bullosa

 描述(由申请人提供)：本赠款申请请求支持将于2015年5月3日至6日在佐治亚州布拉塞尔顿举行的“EB2015：Debra大疱性表皮松解症国际研讨会”会议。这次会议是关于大疱性表皮松解症(EB)的一系列三年一次的研究会议的一部分。EB是一种毁灭性的可遗传水泡疾病，目前还没有有效的治疗或治愈方法。这些会议由全球患者倡导组织联盟Debra International赞助，本次会议的东道主和组织者将是Debra America，这是一个代表EB患者及其家人进行倡导的非营利性组织。本次研讨会的总体目标是为致力于皮肤脆性综合征和EB光谱相关领域的首屈一指的科学家提供一个国际论坛。组委会制定了一项计划，具体目的是促进对EB临床问题的更好了解；介绍和讨论EB的前沿科学研究进展；促进基础科学家和临床医生之间的合作；并为该领域的学生、博士后研究员和年轻研究人员提供对皮肤病的发病机制和治疗感兴趣的机会。专题会议的重点是：(1)阐述挑战；(2)提供患者观点和回顾未得到满足的临床需求；(3)回顾遗传学、基因组学和诊断学方面的基础科学进展；(4)讨论遗传和替代策略的前景；(5)蛋白质和干细胞生物学；(6)诱导多能干细胞技术；(7)组织工程和临床前模型；(8)EB中的癌症和疤痕；(9)临床试验的最新进展；以及(10)展望EB疗法的商业化。观众预计将有约150人参加，其中包括该领域相当数量的年轻和新的调查人员--学生、研究员和初级教员。组织者还将与代表不足的少数群体社区进行接触，邀请并鼓励他们参加这次会议，以建立一个未来皮肤生物学特别是EB领域少数群体研究人员的渠道。我们认为，计划中的会议是非常及时的，预计它将证明它在为未来的研究主题带来跨学科方法方面是有用的，重点是开发治疗EB和相关可遗传水泡性疾病的分子方法，甚至可能是治愈方法。

 DESCRIPTION (provided by applicant): This grant application requests support for a meeting, "EB2015: DEBRA International Symposium on Epidermolysis Bullosa", to be held on May 3-6, 2015, in Braselton, GA. The conference is part of a series of triennial research meetings on epidermolysis bullosa (EB), a devastating heritable blistering disease for which there is no effective treatment or cure. These meetings are sponsored by DEBRA International, the coalition of global patient advocacy organizations, and the host and the organizer of this meeting will be DEBRA America, a not-for-profit organization advocating on behalf of patients with EB and their families. The overall goal of this symposium is to provide an international forum for the cadre of premiere scientists working in fields relating to skin fragility syndromes i the spectrum of EB. The organizing committee has developed a program, with the specific aims to foster a greater understanding of the clinical problems of EB; present and discuss advances in cutting edge scientific research on EB; promote collaboration between basic scientists and clinicians; and provide opportunities for students, post-doctoral fellows and young investigators in the field with interest in pathogenesis and treatment of cutaneous diseases. The thematic sessions focus on (1) framing the challenges; (2) provide patient perspectives and review the unmet clinical needs; (3) review the basic science advances in genetics, genomics and diagnostics; (4) discuss prospects of genetic and replacement strategies; (5) protein and stem cell biology; (6) induced pluripotent stem cell technologies; (7) tissue engineering and preclinica models; (8) cancer and scarring in EB; (9) update on clinical trials; and (10) looking ahead to commercializing EB therapies. The audience is expected to consist of ~150 participants, including a significant number of young and new investigators in the field - students, fellows, and junior faculty. The organizers will also reach out to communities of under-represented minorities with invitations and incentives to participate in this meeting, towards building a pipeline of future minority researchers in cutaneous biology and particularly EB. We believe that the planned meeting is extremely timely, and it is expected to prove its usefulness in bringing interdisciplinary approaches for the research themes for the future with focus on developing molecular approaches for treatment, and perhaps a cure, for EB and related heritable blistering diseases.