Training in Translational Science and Cardiovascular Medicine

描述（由申请人提供）：此延续提案寻求资金用于心血管疾病转化研究的培训项目。该项目通过俄勒冈健康与科学大学心血管医学部和心脏研究中心招收博士和医学博士实习生。每年资助6名博士后进行为期两年的研究培训。这个项目提供了令人兴奋的机会，可以在三个已建立的专业小组中进行从实验室到床边的培训：1)肥胖/糖尿病，2)发育规划，3)调节过程。28名教师都是备受认可和资助的科学家，他们在培养博士后方面有着良好的记录。专业培训包括分子成像、小鼠遗传模型、肥胖和心血管疾病的灵长类动物模型、临床MRI研究、机械力-基因表达联系、生物工程血管元件、心血管失调的数学模型。实验室研究辅以课程作业、研讨会、期刊俱乐部和特定科学小组的会议。所有学员参加负责任的研究行为培训和团队科学方法。这个项目在OHSU是独一无二的，因为指导是以团队方式进行的，因为这个培训项目是专门为将基础研究转化为临床效益而设计的。一名基础科学家和一名临床科学家以及一名额外的科学家在每个实习生的指导委员会中任职。培训的结果将是具有广阔视野和专注于将科学带到床边的科学家。该应用程序包括针对服务不足的少数族裔学员的强大招聘计划和评估程序。一个强大的项目咨询委员会监督每一个学员的进展，因为他们达到了特定的里程碑，为研究事业做准备。从这个项目毕业的科学家将准备调查主要的公共卫生问题，包括日益增加的中风、糖尿病、冠心病、心力衰竭和肥胖的全球负担。（摘要结束）

DESCRIPTION (provided by applicant): This continuation proposal seeks funds for a training program in translational research applied to cardiovascular disease. The program recruits PhD and MD trainees through the Division of Cardiovascular Medicine at Oregon Health & Science University and the Heart Research Center. Six post-doctoral fellows per year are offered funding for two years of research training. The program offers exciting opportunities for bench to bedside training in one of three established groups that specialize in 1) obesity/diabetes, 2) developmental programming, and 3) regulatory processes. The 28 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training includes molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, bioengineering vascular elements, mathematical models of cardiovascular dysregulation. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. All trainees participate in Responsible Conduct of Research training and team science methods. This program is unique at OHSU in that mentoring is carried out in a team approach and because this training program is specifically designed to translate basic research into clinical benefit. A basic scientist and a clinical scientist plus on additional scientist serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. The scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity. (End of Abstract)