Asymmetric Synthesis of Biologically Active Marine Natural Products

研究天然产物的合成提供了丰富的机会， 化学和生物学方向。我们研究计划的首要目标是研究 医药相关小分子的化学合成和促进化学 下一代药物合成技术。通过这个项目，我们将更好地 了解自然界如何进行环加成型二聚反应，以产生更高的 吡咯咪唑类生物碱。我们将测试生物合成假说， 这些天然产物的仿生合成方法。灵感来自于 金属酶，我们将进一步开发用于C-H和烯烃氧化的新催化剂体系。我们 还将研究环状二核苷酸如何介导先天免疫反应。我们的研究将有 对小分子药物的发现和制造产生直接影响。

Studying the synthesis of natural products provides rich opportunities for identifying new directions in chemistry and biology. The overarching goal of our research program is to study the chemical synthesis of small molecules of medicinal relevance and to advance chemical technology for the next-generation of drug synthesis. Through this project, we will better understand how nature performs cycloaddition-type dimerization reactions to produce higher order pyrrole-imidazole alkaloids. We will test the biosynthetic hypotheses and develop biomimetic synthetic approaches to these natural products. Inspired by the oxidative metalloenzymes, we will further develop new catalyst systems for C-H and olefin oxidation. We will also study how cyclic dinucleotides mediate innate immune response. Our research will have direct impacts on the discovery and manufacturing of small-molecule drugs.