2015 Directed Cell Migration Gordon Research Conference & Gordon Research Seminar

描述（由申请人提供）：戈登方向细胞迁移研究会议的目标是为传播和讨论细胞迁移前沿的新研究，概念和机会提供一个激励论坛。Peter Devreotes和Jeff Segall在2005年组织了第一次会议，他们设想开发一个论坛，促进对梯度传感和定向细胞迁移有浓厚兴趣的科学家之间的互动。10年后，该会议被认为是细胞迁移方面的顶级研究会议。2015年会议的计划将于1月24日至30日在德克萨斯州加尔维斯顿的加尔维斯酒店举行，旨在汇集来自不同学科的细胞迁移科学家，包括分子和细胞生物学家，工程师和物理学家。重点将放在（1）在信号转导和肌动蛋白组装水平上细胞迁移的基本机制，（2）包括研究模型系统和体内系统的研究人员，（3）发育过程中细胞迁移的研究，白细胞运输，伤口愈合，以及癌症侵袭和转移，以及（4）在二维和三维环境中比较和对比单细胞与集体细胞迁移。会议的目的是：（1）提供一个论坛，讨论定向细胞迁移领域的前沿研究， 特别侧重于多学科方法和协作科学，（2）促进研究定向细胞迁移的科学家之间的正式和非正式科学交流，包括青年科学家、妇女和来自代表性不足的少数民族背景的科学家，（3）讨论特别是与癌症侵袭和转移生物学相关的最新进展。为实现这些目标，2015年会议将汇集一批来自学术界的青年和资深科学家，他们将在有利于自由交流思想的氛围中进行互动。与2013年一样，2015年GRC之前将举办由年轻研究人员（Ritankar Majumdar和Shirin Pocha）组织的关于定向细胞迁移的GRS，重点是在细胞迁移研究中使用多学科方法。这项活动将有助于培养初级研究人员在细胞迁移领域取得成功和有价值的职业生涯。GRS将由Andrew Ewald（JHU）主持开幕，他将讨论集体乳腺癌侵袭的新范式。GRS的闭幕演讲将由Xavier Trepat（西班牙加泰罗尼亚生物工程研究所）发表，主题是控制 通过细胞间粘附体的集体细胞迁移。从摘要和两个海报会议中选出的八个演讲将允许参与互动和讨论。此外，还将包括一个非正式的“问PI”研讨会，由主席和主旨发言人参加，讨论细胞迁移领域的职业发展问题。对全球资源中心和全球资源中心而言，财政支助将确保会议取得成功，并为受邀发言者和其他选定与会者的旅行和登记提供必要的赞助。

DESCRIPTION (provided by applicant): The goal of the Gordon Research Conference on Direction Cell Migration is to provide a stimulating forum for the dissemination and discussion of new research, concepts and opportunities at the forefront of cell migration. Peter Devreotes and Jeff Segall, who organized the first meeting held in 2005, envisioned developing a forum fostering interactions among scientists with a strong interest in gradient sensing and directed cell migration. After 10 years, the conference is considered to be the top research conference in cell migration. The program for the 2015 conference, to be held January 24-30 at Hotel Galvez, Galveston, TX, is aimed at bringing together cell migration scientists from diverse disciplines, including molecular and cell biologists, engineers and physicists. A strong emphasis will be placed on (1) basic mechanisms of cell migration at the levels of signal transduction and actin assembly, (2) inclusion of researchers that work with model systems as well as in vivo systems, (3) the study of cell migration during development, leukocyte trafficking, wound healing, and cancer invasion and metastasis and (4) comparing and contrasting single-cell versus collective cell migration in 2- and 3-dimensional environments. The aims of the conference are to: (1) provide a forum for the discussion of cutting edge research in the area of directed cell migration, with a particular focus on multidisciplinary approaches and collaborative science, (2) promote both formal and informal scientific exchanges among scientists investigating directed cell migration, including young scientists, women and scientists from underrepresented minority backgrounds, and (3) discuss recent advances especially relevant to the biology of cancer invasion and metastasis. To accomplish these aims, the 2015 Conference will bring together an international cadre of young and senior scientists from academia that will interact in an atmosphere conducive to the free exchange of ideas. As in 2013, the 2015 GRC will be preceded by a GRS on Directed Cell Migration, organized by young researchers (Ritankar Majumdar and Shirin Pocha), with focus on using multidisciplinary approaches in the study of cell migration. This event will help nurture junior researchers towards a successful and rewarding career in the field of cell migration. The GRS will be opened by Andrew Ewald (JHU), who will discuss new paradigms in collective breast cancer invasion. The closing GRS lecture will be given by Xavier Trepat (Institute for Bioengineering of Catalonia, Spain) on the control of collective cell migration by intercellular adhesome. Eight talks selected from the abstracts and two poster sessions will allow for engaged interactions and discussions. In addition, an informal "Ask the PI" seminar with the Chairs and Keynote Speakers on career development in the field of cell migration will be included. For both, the GRC and GRS, financial support will assure that the meeting will be successful and provide needed sponsorship for travel and registration of invited speakers and other selected participants.