Childhood Cancer Survivor Study

描述(由申请人提供)：儿童癌症幸存者研究(CCSS)是一个多机构、多学科的合作研究资源，旨在系统地评估确诊后存活五年或更长时间的儿童癌症患者的长期结果。CCSS包括储存的生物标本、关于癌症诊断的详细信息、与治疗相关的暴露和结果，是可用于促进儿科癌症幸存者长期研究的最大综合资源。从1994年开始招募最初的队列，其中包括1970年至1986年期间确诊的21岁以前特定癌症的幸存者和幸存者的兄弟姐妹，并于2008年开始扩大队列，其中包括1987年至1999年确诊的5年幸存者。扩展完成后，合并后的队列将包括37,750多名符合条件的幸存者，他们有详细的治疗暴露信息，可用于最近的调查 死亡率。在符合条件的队列中，估计有26,000至27,000名活跃的幸存者参与者将提供与健康有关的详细结果和生活质量。研究界对CCSS资源的广泛使用取得了以下成果：160篇发表和出版的手稿；143篇摘要/演示文稿；29项由研究人员发起的赠款(总额约为2470万美元)；对31名学生/新研究人员进行了正式培训；17项分子遗传学研究；进行了4项随机干预试验；增加了为基于暴露的临床随访指南提供信息的知识；以及为儿童癌症生存研究的多项国际倡议建立了一个非常成功的模式。在接下来的五年里，活动的重点将是维护、加强和最大限度地利用这一独特的资源。CCSS资源的首要目标是增加与儿童癌症存活率相关的创新和高影响力研究的开展。

DESCRIPTION (provided by applicant): The Childhood Cancer Survivor Study (CCSS), a multi-institutional, multi-disciplinary collaborative research resource, was established to systematically evaluate long-term outcomes among childhood cancer patients who survived five or more years from diagnosis. The CCSS, which includes banked biospecimens, detailed information on cancer diagnosis, treatment-related exposures, and outcomes, is the largest comprehensive resource available to facilitate the long-term study of pediatric cancer survivors. Recruitment of the initial cohort, consisting of survivors of specific cancers diagnosed prior to 21 years of age between 1970 and 1986 and a cohort of siblings of survivors, began in 1994, In 2008, expansion of the cohort with five-year survivors diagnosed between 1987 and 1999 was initiated. When expansion is complete, the combined cohort will include more than 37,750 eligible survivors with detailed treatment exposure information available for investigation of late mortality. Among the eligible cohort, an estimated 26,000 to 27,000 active survivor participants will contribute detailed health-related and quality of life outcomes. Extensive use of the CCSS resource by the research community has resulted in: 160 published and in press manuscripts; 143 abstracts/presentations; 29 investigator-initiated grants (totaling approximately $24.7 million); formal training of 31 students/new investigators; 17 molecular genetics investigations; the conduct of 4 randomized intervention trials; increased knowledge to inform exposure-based clinical follow-up guidelines; and, a highly successful model for multiple international initiativs of pediatric cancer survivorship research. During the next five years, activities will focus on maintaining, enhancing, and maximizing use of this singular resource. The overarching goal of the CCSS resource is to increase the conduct of innovative and high impact research related to pediatric cancer survivorship.