Analysis of Linked NHIS Registry Data

描述(由申请人提供)：美国癌症监测历来分散的性质，加上保护患者和调查受访者机密性的迫切需要，阻碍了将癌症登记与国家代表性健康研究联系起来的努力。这种数据联系的扩展具有巨大的潜力，可以进一步扩大癌症连续体的差异。自1986年以来，200多万人参加了由国家健康统计中心(NCHS)进行的具有全国代表性的健康调查，包括国家健康访谈调查(NHIS)。在与NCHS主要成员的密切合作下，迈阿密大学的研究人员最近完成了与NHIS调查数据和佛罗里达州癌症登记系统(FCDS)的联系，佛罗里达州癌症数据系统(FCDS)每年识别美国6%的癌症病例。来自NHIS的合格记录超过170万条，来自FCDS的合格记录超过250万条，这导致了一个包含7483例癌症病例的最终关联和极大丰富的数据集。这一链接现在位于NCHS研究数据中心(RDC)，对间接分析访问具有严格的机密性控制。我们的长期目标是 创建一个联合体，利用NCHS调查的记录与美国所有癌症登记机构建立数据联系。一旦成立，这个联盟将使我们能够创建一个高度丰富的数据库，其中包括在参与具有全国代表性的NCHS调查之前和之后被诊断为癌症的大约96,000人或更多人，创建癌症幸存者和未来癌症病例的独特队列。在承担建立这个联合体的复杂任务之前，我们寻求R03资金来分析这些数据，目的是展示与关键利益相关者的联系的效用，并收集未来电力计算所需的数据。我们的研究目标包括：1)记录FCDS确定的癌症幸存者的健康行为、健康和发病率状况；与NHIS访谈时未患癌症的人进行多变量比较；2)记录NHIS访谈时未患癌症的人癌症发病的预测因素；3)记录癌症幸存者和继续罹患癌症的参与者的死亡率趋势变化；4)通过在有针对性的同行评议出版物上发表演讲和出版物，向主要利益攸关方传播研究结果，以促进联盟的发展。

DESCRIPTION (provided by applicant): The historically de-centralized nature of cancer surveillance in the United States, combined with the paramount need for the protection of patient and survey respondent confidentiality, has hampered efforts to perform cancer registry linkages with nationally representative health studies. Expansion of such data linkages has enormous potential for furthering the disparities along the cancer continuum. Since 1986, over two million people have participated in nationally representative health surveys undertaken by the National Center for Health for Health Statistics (NCHS) including the National Health Interview Survey (NHIS). In close collaboration with key NCHS members, Investigators at the University of Miami have recently completed a linkage with NHIS survey data and the Florida cancer registry, the Florida Cancer Data System (FCDS), which annually identifies 6% of all cancer cases in the US. There were over 1.7 million eligible records from the NHIS and 2.5 million eligible records from the FCDS, which resulted in a final linked and greatly enriched dataset of 7,483 cancer cases. This linkage is now housed at the NCHS Research Data Center (RDC) with strict confidentiality controls for indirect analysis access. Our long-term objective is to create a Consortium to perform data linkages utilizing the records from the NCHS surveys with all US cancer registries. Once in place, this Consortium will enable us to create a highly enriched database of an estimated 96,000 or more persons diagnosed with cancer before and after their participation in the nationally-representative NCHS surveys, creating unique cohorts of both cancer survivors and future cancer cases. Prior to undertaking the complex task of building this Consortium, we seek R03 funding to analyze these data for the purpose of demonstrating the utility of the linkage to key stakeholders and to gather data needed for future power calculations. Our study Aims include: 1) Document health behavior, health and morbidity status of FCDS-identified cancer survivors; perform a multivariable comparison with those cancer-free at the time of their NHIS interview; 2) Document predictors of cancer onset in those cancer-free at the time of their NHIS interview; 3) Document changes in mortality trends of cancer survivors and among participants who go on to develop cancer; 4) Disseminate study findings to key stakeholders through presentations and publications in targeted peer-reviewed publications to promote development of the Consortium.