Improving Antiretroviral Management for HIV

描述（由申请人提供）：此K24更新申请的目标是允许申请人继续指导追求临床HIV调查职业生涯的学员。该申请将提供持续的机会，利用正在进行和计划的临床研究，通过UCSD AVRC，加州合作治疗组（CCTG）和综合临床系统（CNICS）的CFAR网络，指导传染病研究员，初级教师和研究生在艾滋病毒相关的临床研究项目，并继续扩大申请人在UCSD临床研究培训计划的参与。目标中概述的研究为深入指导以及调查艾滋病毒管理和发病机制中及时和重要的科学问题提供了机会。对于每个目标和子目标，学员是研究的主要领导者：学员从一开始就与申请人合作开发研究，并将参与方案开发，研究执行，统计分析，结果解释，结果展示和出版的各个方面。所有主要研究都得到了资助（学员参与了赠款编写过程），对于实验室次级目标，学员参与了最近提交的赠款申请。 指导的目标将通过实施2项科学目标来实现，其中包括几项临床研究。具体目标1：分析CNICS队列数据，以评价抗逆转录病毒（ARV）暴露的趋势以及由此产生的病毒学和耐药性结局，包括女性和非裔美国人结局的差异。临床研究：CNICS 002、CNICS 019以及正在开发的新CNICS概念提案。具体目标2：研究提高抗逆转录病毒治疗依从性和减少高危行为的技术和行为方法，以潜在地减少HIV感染受试者的传播。临床研究：CCTG 592和开发中的新CCTG研究。 该项目的目标是让首席研究员继续指导在临床艾滋病毒调查中追求职业生涯的学员。该应用程序将提供持续的机会，利用正在进行和计划的临床研究，通过UCSD AVRC，加州合作治疗组（CCTG）和综合临床系统（CNICS）的CFAR网络，在艾滋病毒相关的临床研究项目中指导传染病研究员，初级教师和研究生。最终，该项目将有助于确保下一代科学家能够应对改善艾滋病毒感染者的科学和治疗的挑战。

DESCRIPTION (provided by applicant): The goal of this K24 renewal application is to allow the applicant to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS) and to continue to expand the applicant's participation in the UCSD training programs for clinical research. The studies outlined in the aims provide opportunities for in-depth mentoring as well as investigation of timely and important scientific questions in HIV management and pathogenesis. For each of the aims and sub-aims, a mentee is the primary leader of the study: trainees have worked with the applicant to develop the studies from the inception and will participate in every aspect of protocol development, study execution, statistical analyses, results interpretation, presentation and publication of the results. All of the main studies are funded (mentees participated in the grant writing process) and for laboratory sub-aims, trainees have participated in recently submitted grant applications. The goal of mentoring will be achieved through the conduct of 2 scientific aims which incorporate several clinical studies. SPECIFIC AIM 1: To analyze CNICS cohort data to evaluate trends in antiretroviral (ARV) exposure and resultant virologic and resistance outcomes including disparities in outcome among women and African Americans. Clinical Studies: CNICS 002, CNICS 019 plus new CNICS concept proposal in development. SPECIFIC AIM 2: To investigate technologic and behavioral methodologies which improve adherence to ARV and reduce high-risk behavior in order to potentially reduce transmission from HIV- infected subjects. Clinical studies: CCTG 592 and new CCTG studies in development. The goal of this project is to allow the Principal Investigator to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS). Ultimately, the project would help to ensure that the next generation of scientists is available to meet the challenges of improving science and treatment of HIV infected patients.