Training of Surgeons for Studies of the Tumor Microenvironment

 描述（由申请人提供）：这是一个新的资金申请，以支持露丝L。Kirschstein NRSA机构研究培训补助金（T32），题为“肿瘤微环境研究外科医生培训”。该计划是专为外科住院医生在外科花两年时间致力于培训的基础和转化研究的行为。我们的计划的目标是提供一个全面的课程，培训外科住院医生在基础实验室研究的重点是肿瘤微环境的研究进行。肿瘤是复杂的假器官，除了肿瘤细胞本身外，还由多种细胞类型组成。认识到这些细胞类型相互作用，创造一个新的肿瘤微环境，导致肿瘤病理生理学的理解和识别癌症治疗的新靶点的重要进展。对控制侵袭和转移的机制以及免疫系统在肿瘤生长抑制中的作用的理解的进展是宿主细胞和肿瘤细胞之间协调的例子。通过汇集一个团队的导师与研究成果的良好记录，以及在培训研究生研究员的持续经验，我们计划解决未满足的需求，在外科医生的职业生涯在癌症研究的准备。我们的应用程序包括优秀的教师导师和共同导师代表6个临床部门和4个基础科学部门。15名教师包括9名高级导师，3名共同导师和3名教育工作者。我们的目标是通过为未来的外科医生科学家提供在科学事业中取得成功所需的工具来改善他们的培训。培训计划将包括两年的实验室研究，正式课程和参加相关的期刊俱乐部和研讨会。培训还将包括参加外科部门的年度研究日，参加部门和专业会议以及相关研讨会。成功的受训者在完成培训方案之前将至少向国家会议提交两份摘要，并至少提交一份供同行审查的原稿。该课程的目的是准备实习生追求的职业生涯作为一个外科医生科学家。该计划的结构与一个正式的评估过程，以评估学员，导师和整体计划的表现。

 DESCRIPTION (provided by applicant): This is a new application for funds to support The Ruth L. Kirschstein NRSA Institutional Research Training Grant (T32) titled "Training of Surgeons for Studies of the Tumor Microenvironment". The program is designed for surgical residents in the department of surgery to spend two years dedicated to training in the conduct of basic and translational research. The goal of our program is to provide a comprehensive curriculum for training surgical residents in the conduct of basic laboratory research focused on the study of the tumor microenvironment. Tumors are complex pseudo organs made up of a variety of cell types in addition to the tumor cells themselves. The recognition that these cell types interact with one another to create a novel tumor microenvironment has lead to important advances in both the understanding of tumor pathophysiology and in the identification of novel targets for cancer therapy. Advances in the understanding of the mechanisms controlling invasion and metastasis as well as the role of the immune system in tumor growth inhibition are examples of the coordination between host cells and neoplastic cells. By bringing together a team of mentors with a strong track record of research accomplishments as well as sustained experience in training post-graduate fellows, we plan to address an unmet need in the preparation of surgeons for a career in cancer research. Our application includes outstanding faculty mentors and co-mentors representing 6 clinical departments and 4 basic science departments. The 15 faculty members include 9 senior mentors, 3 co-mentors and 3 educators. Our goal is to improve the training of future surgeon scientists by providing them with the tools necessary to succeed in a scientific career. The training program will consist of two years of laboratory research, formal coursework and participation in relevant journal clubs and seminars. The training will also include participation in the department of surgery's annual research day and attendance at departmental and professional conferences and relevant workshops. Successful trainees will have submitted at least two abstracts to national meetings and at least one original manuscript for peer review by the completion of the training program. The curriculum is designed to prepare the trainee to pursue a career as a surgeon scientist. The program is structured with a formal evaluation process in place to evaluate trainee, mentor and overall program performance.