Nebraska Center for Cellular Signaling

描述(由申请人提供)：这份Cobre第三阶段申请建议继续内布拉斯加州细胞信号中心，该中心是为了加强内布拉斯加州大学医学中心(UNMC)内的研究而建立的。这项应用的具体目标是：目标1：提供支持，以支持细胞信号领域的新研究人员的合作研究和指导。目标2：加强对隶属于NCCS的研究人员的研究能力、创新和资金支持。目标3：使NCCS从IDEA资助中毕业，成为一个自给自足的细胞信号卓越研究中心。该中心是由科布雷计划提供的第一阶段和第二阶段资金建立的。该中心宣布的目标是1)扩大目前对细胞信号转导的关注；2)提高内布拉斯加州研究型大学，特别是UNMC牙科学院的研究知名度；3)促进有前途的年轻教师的发展，使他们成为科学界的杰出成员，这体现在NIH的巨额资金、重要手稿的出版、审查小组的服务和全国各地的演讲邀请上。我们以非凡的成功实现了我们的每一个目标。随着我们的基础设施到位，9名初级助理教授获得了ROI或主要的ACS支持。牙科学院新招聘的四名教员中，有三名在这九名教员中。我们制定了旨在加强和维持该中心的计划，包括支持合作项目、持续的研讨会计划以及核心和专业开发团队的利用。我们职业发展计划的成功体现在任命我们的毕业生进入编辑委员会，在评论小组担任成员或主席，并邀请他们出席研讨会。我们得到了该机构的大力支持，并制定了在Cobre资金到期后维持该中心的计划。PI和联席董事致力于延续我们的指导文化和成功文化。该中心的成立所产生的合作环境已经并将继续加强内布拉斯加州研究机构内的研究和研究基础设施。

DESCRIPTION (provided by applicant): This COBRE Phase III application proposes to continue The Nebraska Center for Cellular Signaling which was established to strengthen research within the University of Nebraska Medical Center (UNMC). The Specific Aims of this application are: Aim 1: Provide support to sustain collaborative research and mentoring of new investigators in the realm of cellular signaling. Aim 2: Strengthen research capabilities, innovation, and funding support for investigators affiliated with the NCCS. Aim 3: Graduate the NCCS from IDeA funding as a self-sustaining center of research excellence in cellular signaling. The Center was established with Phase I and II funding from the COBRE program. The stated objectives of the Center were 1) to expand the current focus on cellular signaling; 2) to increase the research profile of research universities in Nebraska, especially the College of Dentistry of UNMC, and 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. We have accomplished each of our goals with exceptional success. With our infrastructure in place, nine beginning Assistant Professors received ROI or major ACS support. Three of the four new faculty recruited to the College of Dentistry are among these nine. We have instituted programs designed to enhance and sustain the Center, including support for collaborative projects, ongoing seminar programs, and utilization of cores and a professional development team. The success of our career development programs is shown by appointments of our graduates to editorial boards, service on review panels as members or chairs, and invitations to present seminars. We have strong support from the institution with plans in place to sustain the Center when COBRE funding expires. The PI and co-directors are committed to continuing our culture of mentoring and our culture of success. The collaborative environment resulting from the formation of the Center has and will continue to enhance research and the research infrastructure within Nebraska's research institutions.