Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer

摘要/项目摘要 该计划的目的是改善锥形束计算机断层扫描（CBCT）成像， 一种介入C形臂，特别是用于引导肝肿瘤的导管引导栓塞，以及多种其它的介入C形臂， 介入手术。肝导管定向治疗的当前护理标准使用 介入C形臂和注射造影剂以显示肿瘤及其供血血管。C形臂CBCT可以 用于了解病变解剖结构，允许肿瘤和供血血管的3D可视化。 然而，由于许多重要的缺陷，当前的C形臂CBCT远未针对应用进行优化。 有关检查时间、辐射剂量、图像质量和对工作流程的侵入性的限制。这些 可以通过开发创新的CBCT扫描和基于优化的 重建。在该项目中，我们专注于解决C形臂CBCT在图像中的实际局限性， 通过创新扫描和基于优化的开发， 重建，并证明其转化为图像引导的肝脏肿瘤的临床任务的潜力 治疗该项目的具体目标包括（1）开发基于优化的重建， 改进当前的C形臂成像，（2）开发扫描和基于优化的重建，以进一步 改善C型臂成像，以及（3）验证、表征和评估基于优化的重建。的 该项目的临床和技术意义很高，因为它可以直接影响重大 肝癌和其他形式的癌症，特别是肺癌和肾癌的干预和治疗，以及 因为它可以导致先进的C臂CBCT技术的发展， 挑战，如稀疏视图，截断，和有限的角度范围的问题，非常高的实际 功该项目具有很高的创新水平，因为它包括许多创造性的想法和方法， 增强工作流程并用于减少造影剂体积、辐射剂量和患者不适。

Abstract/Project Summary The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other interventional procedures. The current standard of care for hepatic catheter directed therapy uses an interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels. However, current C-arm CBCT is far from being optimized for the application due to a number of important limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These limitations can be addressed through the development of innovative CBCT scans and optimization-based reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image- guided liver-tumor catheter delivery through the development of innovative scans and optimization-based reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The clinical and technical significances of the project are high, because it can directly impact significantly intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and because it can lead to the development of advanced C-arm CBCT technology for addressing technical challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.