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Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer

先进C型臂锥束CT治疗肝癌的开发

基本信息

批准号：
9305887
负责人：
XIAOCHUAN PAN
金额：
$ 43.68万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9305887
关键词：
Address Advanced Development Algorithms Anatomy Asorbicap Catheters Clinical Contrast Media Data Development Dose Evaluation Studies Fluoroscopy Hepatic Image Image Enhancement Image-Guided Surgery Imagery Injectable Interruption Intervention Kidney Lead Lesion Liver Liver neoplasms Lung Malignant Neoplasms Malignant neoplasm of liver Methods Morphologic artifacts Nephrotoxic Noise Operative Surgical Procedures Patients Procedures Protocols documentation Radiation Radiation therapy Research Rotation Sampling Scanning Sterile coverings Techniques Technology Therapeutic Embolization Time Tissues Work arm base cancer therapy clinically significant cone-beam computed tomography design detector feeding hazard image guided image reconstruction imaging modality improved innovation insight liver visualization nephrotoxicity preclinical study prevent programs public health relevance reconstruction standard of care tumor

项目摘要

DESCRIPTION (provided by applicant): The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other interventional procedures. The current standard of care for hepatic catheter directed therapy uses an interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels. However, current C-arm CBCT is far from being optimized for the application due to a number of important limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These limitations can be addressed through the development of innovative CBCT scans and optimization-based reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image- guided liver-tumor catheter delivery through the development of innovative scans and optimization-based reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The clinical and technical significances of the project are high, because it can directly impact significantly intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and because it can lead to the development of advanced C-arm CBCT technology for addressing technical challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.

描述（由申请人提供）：该计划的目的是改进在介入 C 形臂上进行的锥形束计算机断层扫描 (CBCT) 成像，特别是用于引导肝肿瘤的导管定向栓塞，以及多种其他介入手术。目前肝导管定向治疗的护理标准使用介入 C 形臂和注射造影剂来观察肿瘤及其供血血管。 C 臂 CBCT 可用于了解病变解剖结构，实现肿瘤和喂养血管的 3D 可视化。然而，由于检查时间、辐射剂量、图像质量和工作流程侵入性等方面的一些重要限制，当前的 C 形臂 CBCT 远未针对应用进行优化。这些限制可以通过开发创新的 CBCT 扫描和基于优化的重建来解决。在该项目中，我们重点通过开发创新扫描和基于优化的重建来解决 C 型臂 CBCT 在图像引导肝脏肿瘤导管输送中的实际局限性，并展示其在图像引导肝脏肿瘤治疗临床任务中的转化潜力。该项目的具体目标包括 (1) 开发基于优化的重建以改进当前的 C 形臂成像，(2) 开发扫描和基于优化的重建以进一步改进 C 形臂成像，以及 (3) 验证、表征和评估基于优化的重建。该项目具有很高的临床和技术意义，因为它可以直接对肝癌和其他形式的癌症，特别是肺癌和肾癌的干预和治疗产生重大影响，并且可以带动先进C型臂CBCT技术的发展，解决稀疏视野、截断和有限角度范围等技术挑战，具有极高的实用价值。该项目具有高水平的创新性，因为它包含了许多用于增强工作流程以及减少造影剂体积、辐射剂量和患者不适的创意和方法。