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Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer

先进C型臂锥束CT治疗肝癌的开发

基本信息

批准号：
9305887
负责人：
XIAOCHUAN PAN
金额：
$ 43.68万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9305887
关键词：
Address Advanced Development Algorithms Anatomy Asorbicap Catheters Clinical Contrast Media Data Development Dose Evaluation Studies Fluoroscopy Hepatic Image Image Enhancement Image-Guided Surgery Imagery Injectable Interruption Intervention Kidney Lead Lesion Liver Liver neoplasms Lung Malignant Neoplasms Malignant neoplasm of liver Methods Morphologic artifacts Nephrotoxic Noise Operative Surgical Procedures Patients Procedures Protocols documentation Radiation Radiation therapy Research Rotation Sampling Scanning Sterile coverings Techniques Technology Therapeutic Embolization Time Tissues Work arm base cancer therapy clinically significant cone-beam computed tomography design detector feeding hazard image guided image reconstruction imaging modality improved innovation insight liver visualization nephrotoxicity preclinical study prevent programs public health relevance reconstruction standard of care tumor

项目摘要

DESCRIPTION (provided by applicant): The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other interventional procedures. The current standard of care for hepatic catheter directed therapy uses an interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels. However, current C-arm CBCT is far from being optimized for the application due to a number of important limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These limitations can be addressed through the development of innovative CBCT scans and optimization-based reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image- guided liver-tumor catheter delivery through the development of innovative scans and optimization-based reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The clinical and technical significances of the project are high, because it can directly impact significantly intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and because it can lead to the development of advanced C-arm CBCT technology for addressing technical challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.

描述（由申请人提供）：本项目旨在改进在介入C形臂上进行的锥形束计算机断层扫描（CBCT）成像，以指导肝肿瘤的导管导向栓塞，尤其是多种其他介入手术。肝导管导向治疗的当前护理标准使用介入C形臂和注射造影剂来可视化肿瘤及其供血血管。C形臂CBCT可用于了解病变解剖结构，允许肿瘤和供血血管的3D可视化。然而，由于在检查时间、辐射剂量、图像质量和工作流程侵入性方面存在许多重要限制，目前的C形臂CBCT远未针对该应用进行优化。这些局限性可以通过开发创新的CBCT扫描和基于优化的重建来解决。在该项目中，我们专注于通过开发创新扫描和基于优化的重建来解决C形臂CBCT在图像引导肝脏肿瘤导管输送中的实际局限性，并展示其在图像引导肝脏肿瘤治疗临床任务中的转化潜力。该项目的具体目标包括：（1）开发基于优化的重建，以改善当前C形臂成像;（2）开发扫描和基于优化的重建，以进一步改善C形臂成像;以及（3）验证、表征和评价基于优化的重建。该项目的临床和技术意义很高，因为它可以直接影响肝癌和其他形式的癌症，特别是肺癌和肾癌的干预和治疗，并且因为它可以导致先进的C形臂CBCT技术的发展，以解决技术挑战，如稀疏视图，截断和具有极高实用价值的有限角度范围问题。该项目具有很高的创新水平，因为它包含了许多创新的想法和方法，用于增强工作流程和减少造影剂体积，辐射剂量和患者不适。