Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer

先进C型臂锥束CT治疗肝癌的开发

基本信息

  • 批准号:
    9305887
  • 负责人:
  • 金额:
    $ 43.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-07-01 至 2018-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other interventional procedures. The current standard of care for hepatic catheter directed therapy uses an interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels. However, current C-arm CBCT is far from being optimized for the application due to a number of important limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These limitations can be addressed through the development of innovative CBCT scans and optimization-based reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image- guided liver-tumor catheter delivery through the development of innovative scans and optimization-based reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The clinical and technical significances of the project are high, because it can directly impact significantly intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and because it can lead to the development of advanced C-arm CBCT technology for addressing technical challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.
描述(由申请人提供):本项目旨在改进在介入C形臂上进行的锥形束计算机断层扫描(CBCT)成像,以指导肝肿瘤的导管导向栓塞,尤其是多种其他介入手术。肝导管导向治疗的当前护理标准使用介入C形臂和注射造影剂来可视化肿瘤及其供血血管。C形臂CBCT可用于了解病变解剖结构,允许肿瘤和供血血管的3D可视化。然而,由于在检查时间、辐射剂量、图像质量和工作流程侵入性方面存在许多重要限制,目前的C形臂CBCT远未针对该应用进行优化。这些局限性可以通过开发创新的CBCT扫描和基于优化的重建来解决。在该项目中,我们专注于通过开发创新扫描和基于优化的重建来解决C形臂CBCT在图像引导肝脏肿瘤导管输送中的实际局限性,并展示其在图像引导肝脏肿瘤治疗临床任务中的转化潜力。该项目的具体目标包括:(1)开发基于优化的重建,以改善当前C形臂成像;(2)开发扫描和基于优化的重建,以进一步改善C形臂成像;以及(3)验证、表征和评价基于优化的重建。该项目的临床和技术意义很高,因为它可以直接影响肝癌和其他形式的癌症,特别是肺癌和肾癌的干预和治疗,并且因为它可以导致先进的C形臂CBCT技术的发展,以解决技术挑战,如稀疏视图,截断和具有极高实用价值的有限角度范围问题。该项目具有很高的创新水平,因为它包含了许多创新的想法和方法,用于增强工作流程和减少造影剂体积,辐射剂量和患者不适。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Image reconstruction and scan configurations enabled by optimization-based algorithms in multispectral CT.
  • DOI:
    10.1088/1361-6560/aa8a4b
  • 发表时间:
    2017-11-02
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Chen B;Zhang Z;Sidky EY;Xia D;Pan X
  • 通讯作者:
    Pan X
Use of the Hotelling observer to optimize image reconstruction in digital breast tomosynthesis.
使用 Hotelling 观测器优化数字乳腺断层合成中的图像重建。
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XIAOCHUAN PAN其他文献

XIAOCHUAN PAN的其他文献

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{{ truncateString('XIAOCHUAN PAN', 18)}}的其他基金

Algorithm-Enabled Auto-Calibrating Quantitative Dual-Energy CT
支持算法的自动校准定量双能 CT
  • 批准号:
    10448987
  • 财政年份:
    2022
  • 资助金额:
    $ 43.68万
  • 项目类别:
Advanced iterative image reconstruction for digital breast tomosynthesis - Resubmission 01
用于数字乳腺断层合成的高级迭代图像重建 - 重新提交 01
  • 批准号:
    9978584
  • 财政年份:
    2018
  • 资助金额:
    $ 43.68万
  • 项目类别:
Advanced iterative image reconstruction for digital breast tomosynthesis - Resubmission 01
用于数字乳腺断层合成的高级迭代图像重建 - 重新提交 01
  • 批准号:
    10224861
  • 财政年份:
    2018
  • 资助金额:
    $ 43.68万
  • 项目类别:
36th Annual International Conference of the IEEE Engineering in Medicine and Biol
第 36 届 IEEE 医学和生物工程国际年会
  • 批准号:
    8720474
  • 财政年份:
    2014
  • 资助金额:
    $ 43.68万
  • 项目类别:
Digital Specimen Tomosynthesis for Volumetric Imaging of Lumpectomy Specimens
用于肿瘤切除标本体积成像的数字标本断层合成
  • 批准号:
    9085109
  • 财政年份:
    2014
  • 资助金额:
    $ 43.68万
  • 项目类别:
Digital Specimen Tomosynthesis for Volumetric Imaging of Lumpectomy Specimens
用于肿瘤切除标本体积成像的数字标本断层合成
  • 批准号:
    8766676
  • 财政年份:
    2014
  • 资助金额:
    $ 43.68万
  • 项目类别:
Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer
先进C型臂锥束CT治疗肝癌的开发
  • 批准号:
    8616609
  • 财政年份:
    2014
  • 资助金额:
    $ 43.68万
  • 项目类别:
International Symposium on Biomedical Imaging: from Nano to Macro 2011 (ISBI2011)
生物医学成像国际研讨会:从纳米到宏观2011 (ISBI2011)
  • 批准号:
    8133639
  • 财政年份:
    2011
  • 资助金额:
    $ 43.68万
  • 项目类别:
31st Annual International Conference of IEEE Engineeering in Medicine and Biology
第 31 届 IEEE 医学和生物学工程国际会议
  • 批准号:
    7744371
  • 财政年份:
    2009
  • 资助金额:
    $ 43.68万
  • 项目类别:
Optimized Cone-Beam CT for Image-Guided Radiation Therapy
用于图像引导放射治疗的优化锥束 CT
  • 批准号:
    7317899
  • 财政年份:
    2007
  • 资助金额:
    $ 43.68万
  • 项目类别:

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