Training of Arthritis Research Scientists

描述（由申请人提供）：这是密歇根大学流变学培训补助金的修订申请，旨在为职业生涯做好准备 作为系统性风湿性疾病基础、转化或临床研究的独立研究者。拟议的培训项目主任是经验丰富的科学家和导师Alisa Koch博士，他将由大卫福克斯博士和Mariana Kaplan博士协助。学员将专注于与风湿性疾病相关的临床，转化或基础研究。合格的医学博士候选人必须完成成人或儿童流变学的大部分临床培训，并且必须表现出对研究和学术生涯的浓厚兴趣。符合条件的博士拥有生命科学相关领域学位的候选人必须寻求将其职业生涯集中在风湿性疾病研究上。培训计划包括一系列结构化的基础科学讲座和研究会议，旨在为学员提供相关科学领域的概念框架，并深入了解与其研究项目相关的疾病实体。这是由基础，转化和临床研究的相关领域的额外必修课程工作的补充。研究培训期包括至少两年的研究经验，同时临床承诺最少。培训项目的教师导师包括21名医学博士，哲学博士、M.D.博士密歇根大学的终身教职调查人员，其中10人在流变学系，9人在其他系或系，1人在流变学和老年医学系。代表的科学专业领域包括免疫学和炎症，细胞和分子生物学，以及风湿性疾病的临床研究，包括类风湿性关节炎，系统性红斑狼疮（SLE），硬皮病（SSc）和纤维肌痛。这些教师在诸如自身免疫的分子基础，血管生成在炎症中的作用，导致终末器官损伤的免疫细胞和组织细胞之间的相互作用，自身免疫性疾病的血管并发症以及SLE，SSc和纤维肌痛的临床研究等领域都有很好的发现记录。培训计划的研究项目得到了大量外部研究资金的支持，超过20，000平方英尺的实验室空间，密歇根大学风湿病核心研究中心以及大量全身性风湿病患者。流变学的这个部门在学术流变学和相关领域的领导者中有着很好的记录。本提案中概述的教师、设施和培训计划将为扩大这些成就提供一个出色的框架。

DESCRIPTION (provided by applicant): This is a revised application for a Rheumatology Training Grant at the University of Michigan that aims to prepare qualified individuals for careers as independent investigators in basic, translational or clinical research in systemic rheumatic diseases. The proposed Training Program Director is Dr. Alisa Koch, an experienced scientist and mentor, who will be assisted by Drs. David Fox and Mariana Kaplan. Trainees will focus on clinical, translational or basic research related to rheumatic diseases. Eligible M.D. candidates will have completed most of their clinical training in adult or pediatric Rheumatology and must demonstrate a strong interest in research and in an academic career. Eligible Ph.D. candidates, with a degree in a relevant area of the life sciences, must seek to focus their career on rheumatic disease research. The Training Program includes a structured series of basic science lectures and research conferences designed to give trainees a conceptual framework in the relevant areas of science, and a thorough understanding of the disease entities related to their research project. This is supplemented by additional required course work in relevant areas of basic, translational and clinical research. The research training period includes at least two years of research experience, with minimal concurrent clinical commitments. The faculty mentors for the Training Program include 21 M.D., Ph.D., and M.D./Ph.D. investigators with tenure track faculty appointments at the University of Michigan, 10 of whom are in the Division of Rheumatology, nine in other Departments or Divisions, and one in both Rheumatology and Geriatrics. The areas of scientific expertise represented include immunology and inflammation, cell and molecular biology, and clinical investigation in the rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus (SLE), scleroderma (SSc), and fibromyalgia. These faculty have a strong record of discovery in areas such as the molecular basis of autoimmunity, the role of angiogenesis in inflammation, interactions between immune cells and tissue cells that lead to end-organ damage, vascular complications of autoimmune disease, and clinical investigations in SLE, SSc and fibromyalgia. The research programs of the Training Program are supported by substantial external research funding, more than 20,000 square feet of laboratory space, the University of Michigan Rheumatic Diseases Core Research Center, and large cohorts of patients with systemic rheumatic diseases. This Division of Rheumatology has a strong record of producing leaders in academic rheumatology and related fields. The faculty, facilities, and training plan outlined in this proposal will provide an outstanding framework for augmenting these accomplishments.