Integrating optical coherence tomography with laryngeal high-speed videoendoscopy

描述（由申请人提供）：临床上越来越需要改进对活体声带组织特性的评估，特别是在人类声音产生过程中测量的动态特性。为了满足这一需求，物理科学公司（PSI）与MGH语音中心合作，将开发一种临床可行的成像系统，该系统将光学相干断层扫描（OCT）与喉部高速视频内窥镜（HSV）相结合。将开发经口内窥镜来评估静息和发声时声带组织的表面外观、表面形状和亚上皮解剖。第一阶段对新鲜小牛喉部的台式测试将包括空间和时间对齐的经验验证以及每种模式的视野优化。PSI/MGH团队将对结果进行数据分析和评估，以继续开发使用不同系统操作模式的有效方法来可视化声带。临床原型将在第二阶段开发，并在人类患者身上进行测试。

DESCRIPTION (provided by applicant): There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address this need, Physical Sciences Inc. (PSI), in collaboration with MGH Voice Center, will develop a clinically-viable imaging system that will integrate optical coherence tomography (OCT) with laryngeal high-speed videoendoscopy (HSV). A transoral endoscope will be developed to assess surface appearance, surface shape, and sub-epithelial anatomy of vocal fold tissue at rest and during phonation. Phase I bench-top testing on fresh calf larynges will include empirical validation of spatial and temporal alignment and optimization of the field of view for each modality. The PSI/MGH team will perform data analysis and assessment of the results to continue to develop effective ways of visualizing the vocal folds using the different modes of system operation. A clinical prototype is proposed to be developed in Phase II and tested on human patients.