Proteomics Facility core

生物信息学核心的使命是协助研究人员和其他核心机构获得数据 管理和信息学，高通量数据收集实验的设计和分析， 用于模式分析和生物建模的计算工具。虽然独立的生物信息学核心 协助SWESHC研究人员满足他们的研究需求，我们认为，一个更优化的结构是一个 其中专门的生物信息学援助嵌入在每个“组学”设施核心中。此外，本发明还提供了一种方法， 我们已经认识到，生物统计学是一个强大的转化研究计划的关键组成部分。 因此，统计/生物信息学资源（SBR）已经形成，并纳入综合 健康科学设施核心（IHS）。为了确保SBR和组学设施核心之间的互动，我们 开发了一种结构，其中基因组学和蛋白质组学核心设施都有专门的 生物信息学/生物计算支持人员在其核心内，同时仍向领导层报告 SBR。这种结构在下面和蛋白质组学和基因组学设施核心文章中描述。的 解散独立的生物信息学核心，并将生物信息学人员纳入蛋白质组学 和基因组学核心设施将确保“组学”核心设施中数据生成之间的有效集成， 生物信息学/生物计算核心中的高维数据分析，以及 分析研究特定的人口统计学/临床信息，以及提供的机制/疾病信息 investigators.这些改变在我们以前的申请中得到了审查小组的好评， 已经在SWEHSC结构中建立。 生物信息学的需求和未来的计划被纳入每个基因组学和蛋白质组学 此应用程序中的设施核心。此外，生物统计学核心，与院长Billheimer博士作为主任， 已制定并纳入综合健康科学设施核心。比尔海默医生的专长 和训练是在分析大数据集，特别是从蛋白质组学分析获得的数据。他将 与基因组学和蛋白质组学中的每个嵌入式生物信息学人员互动并提供帮助。除了 改变现有的生物信息学结构，我们还提出了一个新的生物信息学倡议， 细胞成像。

The Mission of the Bioinformatics Core has been to assist investigators and the other Core Facilities with data management and informatics, design and analysis of high throughput data collection experiments, and computational tools for pattern analysis and biological modeling. While a stand-alone Bioinformatics Core has assisted SWESHC investigators with their research needs, we feel that a more optimal structure is one in which specialized Bioinformatics assistance is embedded within each of the "omic" Facility Cores. In addition, we have recognized that biostatistics is a critical component of a robust translational research program. Therefore, a Statistics/Bioinformatics Resource (SBR) has been formed and incorporated into the Integrated Health Sciences Facility Core (IHS). To ensure interaction between the SBR and the omics facility cores, we developed a structure in which the Genomics and Proteomics Core facilities each have dedicated bioinformatics/biocomputing support personnel within their Core while still reporting to the leadership of the SBR. This structure is described below and in the Proteomics and Genomics Facility Core write-ups. The dissolution of a stand-alone Bioinformatics Core and the incorporation of Bioinformatics staff into Proteomics and Genomics Core facilities will insure efficient integration between data generation in "omics" Core facilities, high-dimensional data analysis in the bioinformatics/ biocomputing core, and the inclusion and statistical analysis of study specific demographic/clinical information, and mechanistic/disease information provided by investigators. These changes were well received by the review panel in our previous application and have already been instituted in the SWEHSC structure. The Bioinformatics needs and plans for the future are incorporated into each of the Genomic and Proteomics Facility Cores in this application. In addition, a Biostatistics Core, with Dr. Dean Billheimer as Director, has been instituted and incorporated into the Integrated Health Sciences Facility Core. Dr. Billheimer's expertise and training are in analysis of large data sets, especially data obtained from proteomics analysis. He will interact with and assist each of the embedded Bioinformatics staff in Genomics and Proteomics. In addition to changes in the existing Bioinformatics structure, we are also proposing a new Bioinformatics initiative in Cellular Imaging.