Examining Innovative Obesity Treatment and Related Novel Constructs

描述（由申请人提供）：此申请是为了获得指导患者导向研究职业发展奖（K23）。候选人Rachel D. Barnes博士对在多学科团队中创新治疗超重和肥胖以及进一步了解新的体重相关变量具有规划性的兴趣。巴恩斯博士计划，作为耶鲁大学医学院（YSM）的初级教员，获得必要的技能，成功获得校外资金，并成为肥胖领域的独立临床研究员。培训和研究计划包括专家指导和合作，Carlos M. Grilo博士，YSM精神病学教授，耶鲁大学心理学教授，肥胖，体重和饮食研究项目主任，以及Deborah Tate博士，Gillings公共卫生学院健康行为和健康教育系联合任命的副教授。以及位于教堂山的北卡罗来纳大学医学院营养学系。这些导师，连同YSM国际公认的贡献者，将协助巴恩斯博士实现和最大化培训和研究计划。巴恩斯博士计划将至少75%的时间用于获取与肥胖相关的行为和心理因素以及超重和肥胖干预方面的进一步知识和专业知识。她为K23提出的具体培训发展目标是：1)获得在不同环境下评估和干预肥胖的更多专业知识；2)设计并实施随机临床试验；3)获得与改进肥胖干预临床方法相关的心理学方法的培训和研究。本应用程序的研究计划由三个相互关联的研究组成，旨在：1)在超重和肥胖治疗寻求样本中验证食物思想抑制量表（FTSI）；2)在暴食症的随机对照试验（RCT）中检验FTSI；3)在初级保健中进行一项创新的随机对照试验，使用易于获得且经济可行的互联网治疗，并辅以动机访谈。总的来说，这些研究将增加巴恩斯博士的伦理知识和进行临床试验的复杂性，包括统计复杂性和方法，并将为R01应用程序的开发提供信息。提出的研究有可能提高我们对基于系统的，广泛的方法来治疗肥胖和新的体重相关结构的理解。K23将帮助巴恩斯博士转型为肥胖症领域的独立临床研究员。

DESCRIPTION (provided by applicant): This application is for a Mentored Patient-Oriented Research Career Development Award (K23). The candidate, Rachel D. Barnes, Ph.D., has a programmatic interest in innovative treatments for overweight and obesity within multidisciplinary teams and furthering understanding of novel weight-related variables. Dr. Barnes plans, as a junior faculty member at Yale University School of Medicine (YSM), to acquire the necessary skills to successfully obtain extramural funding and become an independent clinical researcher in the area of obesity. The training and research plan comprises the expert mentorship and collaboration of Carlos M. Grilo, Ph.D., Professor of Psychiatry at YSM, Professor of Psychology at Yale University, and Director of the Program for Obesity, Weight, and Eating Research, and Deborah Tate, Ph.D., Associate Professor with joint appointments in the Gillings School of Public Health in the Departments of Health Behavior and Health Education, and the Department of Nutrition at the University of North Carolina School of Medicine, Chapel Hill. These mentors, along with internationally recognized contributors from YSM, will assist Dr. Barnes in achieving and maximizing the training and research plans. Dr. Barnes plans to devote a minimum of 75% of her time to obtaining further knowledge and expertise in behavioral and psychological factors associated with obesity and in intervening with overweight and obesity. Her specific training development goals proposed for the K23 are to: 1) Acquire greater expertise with assessing and intervening with obesity in different settings; 2) Design and conduct a randomized clinical trial; and 3) Obtain training and perform research in psychological approaches relevant to improving clinical methods for intervening for obesity. The research plan for this application is comprised of three interrelated studies designed to: 1) Validate the Food Thought Suppression Inventory (FTSI) within an overweight and obese treatment seeking sample; 2) Examine the FTSI within a randomized controlled trial (RCT) for binge eating disorder; and 3) Conduct an innovative RCT treating obesity within primary care using an easily accessible and financially feasible internet treatment enhanced with motivational interviewing. Collectively, these studies will increase Dr. Barnes's knowledge of ethics and complexities of conducting clinical trials, including statistical sophistication and methodologies, and will inform the development of R01 applications. The proposed research has the potential to improve our understanding of a systems based, broad approach to treating obesity and novel weight-related constructs. The K23 will support Dr. Barnes's transition to an independent clinical-researcher in the field of obesity.