2015 Aging, Biology of Gordon Research Conference and Gordon Research Seminar

 描述（由申请人提供）：本申请要求资金支持2015年戈登研究会议（GRC）关于衰老生物学，将于2015年7月19日至24日在星期日河度假村（纽里，缅因州，美国）举行，以及戈登-凯南研究研讨会（GRS），将于7月18日至19日在同一地点举行，就在GRC之前。这将是该系列会议自1962年开始以来的第三十次会议。虽然老年病和 老年学协会及其会议一直强调衰老的医学、社会和心理后果，过去二十年来，关于衰老过程最基本的分子方面的知识激增。在这一领域进行基础研究的研究人员，许多使用无脊椎动物模型系统，越来越多地寻求衰老生物学GRC作为一个很好的论坛，介绍最近的数据和网络。从这一分水岭时期出现，现代概念的生物学老化仍然是一个相对较新的领域，这个GRC已成为首要的论坛，讨论在当前调查的最前沿。因此，衰老的基础生物学和慢性病的调查和治疗的历史上分离的领域已经开始围绕共同的分子原理合并。部分由于衰老生物学GRC的影响，该领域已经接受了阐明长寿的基本机制将促进我们对重要疾病分子基础的基本理解的概念，反之亦然。这些见解预计将导致新的预防和治疗策略，这将对提高老年人的生活质量产生深远的影响。继续，事实上， 2015年会议的主题是老龄化的转化科学：从功能途径到干预。为了促进不同领域研究人员之间的相互反馈，会议围绕以下主题组织：表观遗传学和基因组稳定性，衰老遗传学，端粒和细胞衰老，干细胞和返老还童，蛋白质稳态和自噬，神经内分泌调节，代谢调节和线粒体。会议最后将举行圆桌讨论会，讨论如何制定老龄化和与年龄有关的疾病的治疗策略。我们的组织原则是开发：1）一个专注于告知人类衰老并具有重要治疗意义的机械进步的计划; 2）一个促进实验模型科学家和参与人类生物学研究的科学家之间相互交流的氛围; 3）一个促进既定研究人员和该领域新人之间互动的场所;以及4）促进初级调查员的征聘、留用和职业晋升的战略。

 DESCRIPTION (provided by applicant): This application requests funds to support the 2015 Gordon Research Conference (GRC) on the Biology of Aging, to be held at the Sunday River Resort (Newry, Maine, USA) on July 19-24, 2015, and the Gordon- Kenan Research Seminar (GRS), which will be held at the same location on July 18-19, immediately prior to the GRC. This will be the thirtieth meeting since the inception of this series in 1962. While geriatrics and gerontology societies and their meetings have maintained an emphasis on the medical, social and psychological ramifications of aging, the last two decades have seen an explosion of knowledge on the most fundamental molecular aspects of the aging process. Investigators performing basic research in this area, many using invertebrate model systems, increasingly sought the Biology of Aging GRC as an excellent forum for the presentation of recent data and networking. Emerging from this watershed period, the modern concept of the biology of aging is still a relatively new field, and this GRC has become the premier forum for discussions at the forefront of current inquiry. As a result, the historically separate areas of the basic biology of aging and the investigation and treatment of chronic diseases have begun to merge around common molecular principles. In part due to the influence of the Biology of Aging GRC, the field has embraced the concept that elucidating the basic mechanisms of longevity will advance our fundamental understanding of the molecular basis of important diseases and vice versa. These insights are expected to lead to novel preventive and treatment strategies, which will have a profound impact on enhancing the quality of life for the elderly. To continue, and in fact put this journey in fast forward, the theme of the 2015 conference will be The Translational Science of Aging: From Functional Pathways to Interventions. To catalyze reciprocal feedback between investigators in diverse areas sessions were organized around the following themes: Epigenetics and Genome Stability, Genetics of Aging, Telomeres and Cellular senescence, Stem Cells and Rejuvenation, Protein Homeostasis and Autophagy, Neuroendocrine Regulation, and Metabolic Regulation and Mitochondria. The meeting will conclude with a round-table discussion on developing therapeutic strategies for aging and age-associated diseases. Our organizational principles are to develop: 1) A program that focuses on mechanistic advances that inform human aging and have significant therapeutic implications; 2) An atmosphere that facilitates reciprocal exchange between scientists working in experimental models and those involved in studies of human biology; 3) A venue that promotes interactions among established investigators and newcomers to the field; and 4) A strategy to foster recruitment, retention and career advancement of junior investigators.