Predoctoral Training in the Molecular Biology of Aging

衰老分子生物学博士前培训

• 批准号: 10190750
• 负责人: John M Sedivy
• 金额: $ 19.7万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190750
• 关键词: Biology of Aging; Molecular Biology; Training; pre-doctoral

Aging is a fundamental biological process and age-related diseases have become the leading causes of death in modern societies. The objective of the Brown University Molecular Biology of Aging Predoctoral Graduate Training Program (MBoA) is to train the next generation of scientists to attack the immensely challenging yet important task of understanding and eventually manipulating human aging. In its first four years of operation the MBoA has brought together molecular biologists, computational and population biologists, and clinicians to provide instruction and training to graduate students in the molecular mechanisms of aging. The MBoA provides PhD candidates with a strong academic and experimental foundation in the current landscape of molecular aging research, and equips them with the skills to pursue a research career in this field. Our understanding of aging has reached a watershed in the past 10-15 years that was enabled by the increasing use of forward genetics in simple model systems. Fifteen faculty trainers from seven different departments and two established graduate programs have come together and comprise the MBoA Training Program. Their research interests span from insulin/IGF signaling, chromatin structure, cellular senescence, mitochondrial function and protein quality control to degenerative disorders of the nervous system, heart and cartilage. The experimental systems span from the nematode and Drosophila to mammalian models including the mouse and a variety of cell culture models. Continuing support is requested at the previous level for four trainees per year for a period of five years. The MBoA Training Program operates as a track under the auspices of two existing and well established programs at Brown University, the Molecular Biology, Cell Biology and Biochemistry Graduate Program (MCB), and the Graduate Program in Pathobiology. Candidates for support are drawn from talented students in the program, either in their first year based on academic excellence, or in subsequent years based on the caliber of their research, and are supported for a period of two years. The MCB and Pathobiology programs have different, but with respect to the biology of aging, very complementary and synergistic areas of activity: MCB has expertise in molecular biology and model organisms, and Pathobiology in mammalian and human physiology and pathology. The combination and integration of these approaches is the cornerstone of the philosophy of the MBoA. While research in invertebrate models informs us on the fundamental molecular mechanisms of aging, these principles have to be interpreted in terms of mammalian physiology and ultimately integrated with human pathology. Only an interdisciplinary approach can hope to implement therapies to alleviate the suffering caused by age-associated degenerative processes.

衰老是一个基本的生物学过程，与年龄有关的疾病已成为死亡的主要原因 在现代社会中。布朗大学衰老分子生物学博士前研究生的目标 培训计划（MBoA）旨在培养下一代科学家，以应对目前仍具有巨大挑战性的挑战。 理解并最终控制人类衰老的重要任务。在其运作的头四年中， MBoA将分子生物学家、计算和种群生物学家以及临床医生聚集在一起， 为研究生提供衰老分子机制方面的指导和培训。MBOA 为博士生提供了一个强大的学术和实验基础，在当前的景观， 分子老化研究，并装备他们的技能，追求在这一领域的研究生涯。我们 在过去的10-15年里，人们对老龄化的理解达到了一个分水岭，这是由于人们对老龄化的认识越来越多， 在简单模型系统中使用正向遗传学。来自七个不同部门的十五名教师培训师， 两个既定的研究生课程走到一起，并组成MBOA培训计划。他们的 研究兴趣涵盖胰岛素/IGF信号传导、染色质结构、细胞衰老、线粒体 功能和蛋白质质量控制的神经系统，心脏和软骨的退行性疾病。的 实验系统从线虫和果蝇到哺乳动物模型，包括小鼠和 多种细胞培养模型。要求继续在以前的级别上每年为4名受训人员提供支助 为期五年。MBoA培训计划作为一个轨道下的两个现有的赞助 在布朗大学，分子生物学，细胞生物学和生物化学 研究生课程（MCB）和病理学研究生课程。支持的候选人来自 有才华的学生在该计划中，无论是在他们的第一年基于学术卓越，或在随后的 根据他们的研究口径，并支持为期两年。MCB和 病理生物学程序有不同的，但相对于衰老的生物学，非常互补， 协同作用的活动领域：MCB在分子生物学和模式生物学以及病理生物学方面具有专长 在哺乳动物和人类的生理学和病理学中。这些方法的组合和整合是 这是MBOA理念的基石。虽然对无脊椎动物模型的研究告诉我们， 衰老的基本分子机制，这些原则必须从哺乳动物的角度来解释。 生理学，并最终与人类病理学相结合。只有跨学科的方法才有希望 实施治疗，以减轻与年龄相关的退化过程造成的痛苦。