Behavioral and Physiological Effects of Marijuana on Smoked Cocaine

描述（由申请人提供）： 在KO 1指导研究科学家发展奖的申请中，Ziva库珀博士提出了一个全面的计划，将培训计划与她对研究多种物质滥用的人类实验室模型的兴趣相结合，以成为人类行为药理学领域的独立研究人员。物质很少被单独滥用，因此，确定生理和行为影响，以及与在良好控制的条件下独立和同时施用的滥用药物相关的健康风险，是推进物质滥用治疗领域的一个必要的初步步骤。可卡因依赖人群中滥用大麻的现象十分普遍。虽然已经有大量的研究推进可卡因和大麻依赖独立的治疗，但还没有研究调查对这两种物质依赖的潜在治疗方法。了解大麻和可卡因之间相互作用的确切性质是制定药物治疗策略的重要第一步。拟议研究的研究目的是首先确定实验者施用的大麻与吸食的可卡因组合的行为和生理影响，这些影响导致与药物组合相关的滥用倾向和健康风险。接下来，将使用人类实验室复发模型来确定大麻对吸食可卡因自我给药复发的影响。库珀博士的培训目标是：1）获得在人类实验室中进行精神活性物质研究的方法学、安全性和伦理学方面的更全面知识; 2）获得方法学和数据分析方面的专业知识，用于在人类实验室中研究实验者和自我管理的大麻和吸食可卡因3）研究人类实验室研究的当代统计方法4）提高手稿和资助写作的熟练程度。总的来说，这一奖项将确保库珀博士的成功过渡到一个独立的研究领域的人类行为药理学的物质使用障碍。 公共卫生相关性：尽管吸毒人群中滥用多种物质的现象普遍存在，但人们对流行的混合毒品所增加的滥用倾向和健康风险知之甚少。在可卡因依赖人群中，大麻依赖和滥用是一个公认的现象，但没有研究调查大麻对可卡因复吸的影响。这些研究将通过确定吸食大麻和可卡因的行为和生理影响来填补药物开发的关键空白。

DESCRIPTION (provided by applicant): In this application for a KO1 Mentored Research Scientist Development Award, Dr. Ziva Cooper has proposed a comprehensive plan to integrate a training plan towards becoming an independent researcher in the field of human behavioral pharmacology with her interest in investigating human laboratory models of polysubstance abuse. Substances are rarely abused independently, thus, determining the physiological and behavioral effects, and the health risks associated with abused drugs administered independently and simultaneously under well-controlled conditions is an imperative preliminary step to advance the area of substance-abuse treatment. Abuse of marijuana among the cocaine-dependent population is widespread. Although there has been a great deal of research advancing the treatment of cocaine and marijuana dependence independently, there have been no studies investigating potential treatments for dependence on both substances. Understanding the precise nature of the interaction between marijuana and cocaine is an essential first step to developing pharmacotherapy strategies for their co-abuse. The research aims of the proposed studies are to first determine the behavioral and physiological effects of experimenter-administered marijuana in combination with smoked cocaine that contribute to the abuse liability and health risks associated with the drug combination. Next, the influence of marijuana on relapse to smoked cocaine self-administration will be determined using a human laboratory relapse model. The training goals for Dr. Cooper are to 1) acquire a more comprehensive knowledge of methodology, safety, and ethics of conducting research with psychoactive substances in the human laboratory; 2) gain expertise in methodology and data analysis for research on experimenter and self-administered marijuana and smoked cocaine in the human laboratory 3) research contemporary statistical approaches to human laboratory research 4) increase proficiency in manuscript and grant writing. Overall, this award will ensure Dr. Cooper's successful transition to an independent investigator in the field of human behavioral pharmacology of substance use disorders. PUBLIC HEALTH RELEVANCE: Despite the prevalence of polysubstance abuse among the drug-using population, little is known about the increased abuse liability and health risks associated with popular drug combinations. Marijuana dependence and abuse among the cocaine-dependent population is a well-established phenomenon, yet there have been no studies investigating the influence of marijuana on relapse to cocaine use. These studies will fill a critical gap in medications development for substance-use disorders by determining the behavioral and physiological effects of marijuana smoked with cocaine.