UCSF Liver Core Center

总体描述(由申请人提供)：加州大学旧金山分校(UCSF)肝脏中心是一个由82名基础和临床科学家组成的跨学科联盟，致力于了解肝脏的生物学和病理生物学以及肝脏疾病的治疗。中心成员的研究分为三个基本的生物学主题：(1)肝脏损伤和修复，(2)祖细胞，生长和发育，(3)肝脏生理和新陈代谢。在所有主题中，研究跨越了从工作台到床边，大约一半的中心成员直接参与了临床和转化性研究。从2008年到2013年，该中心将支持三个生物医学研究中心：(1)细胞生物学，(2)肝脏免疫学和细胞分析，(3)病理学。临床部分提供生物统计学支持，以补充加州大学旧金山分校临床和翻译科学研究所提供的服务，是行政核心的一部分。管理核心中还有工具和技术计划；这是一个“用户定义的”或“点菜”的核心，旨在支持成员使用加州大学旧金山分校的核心服务，而不是由中心直接提供。该中心的目标是提供研究支持、技术培训、新合作的场所和新成员的切入点。该中心还通过丰富计划促进科学交流，该计划包括由当地和来访的科学家举办研讨会，每季度举办一次小型研讨会，突出每个研究主题，以及每年一次为期一天的研讨会，并举行生动的海报会议。该中心的一个重要组成部分是其试点/可行性计划，该计划为初级研究人员和新接触研究肝病的科学家提供种子资金。这个奖项计划和核心一样，是一个重要的招聘工具。该中心继续通过与格拉德斯通研究所及其附属机构以及加州大学旧金山分校的其他有组织的研究单位建立战略伙伴关系，扩大对成员科学的支持。该中心的资金基础继续扩大，该机构的支持是持续和强有力的。基础生物学发现和基础科学应用于临床肝病的机会很多；该中心准备催化这些领域的成就。

DESCRIPTION, OVERALL (provided by applicant): The Liver Center of the University of California, San Francisco (UCSF) is an interdisciplinary consortium of 82 basic and clinical scientists dedicated to understanding the biology and pathobiology of the liver and the treatment of liver diseases. Research by Center members is categorized under three basic biological themes: (1) Liver Injury and Repair, (2) Progenitor Cells, Growth and Development and (3) Hepatic Physiology and Metabolism. Across all themes, research spans bench to bedside, with approximately half of Center members being directly involved in clinical and translational studies. From 2008-2013 the Center will support three Biomedical Research Cores: (1) Cell Biology, (2) Liver Immunology & Cell Analysis and (3) Pathology. A Clinical Component, which offers biostatistical support to supplement the services offered by the UCSF Clinical and Translational Science Institute, is part of the Administrative Core. Also within the Administrative Core is the Tool & Technology Program; this is a "user-defined" or "a la carte" core designed to support member use of core services at UCSF not provided directly by the Center. The goals of the Center are to provide research support, technical training, a venue for new collaborations and an entry point for new members. The Center also fosters scientific exchange through an Enrichment Program that features seminars by local and visiting scientists, quarterly mini-symposia highlighting each research theme, and an annual 1-day symposium with a lively poster session. A vital component of the Center is its Pilot/Feasibility Program, which provides seed money to junior investigators and scientists new to investigative hepatology. This award program, like the cores, is an important recruitment vehicle. The Center continues to expand its support of member science through strategic partnerships with the Gladstone Institutes and affiliations, with other organized research units at UCSF. The funding base of the Center continues to grow, and support from the institution is sustained and strong. Opportunities for basic biologic discovery and the application of basic science to clinical liver disease are numerous; the Center is poised to catalyze achievements in these areas.