Research and career training in vertebrate developmental genomics

描述(由申请人提供)：申请资金支持脊椎动物发育基因组学的综合培训计划。该计划将在康奈尔大学脊椎动物基因组学中心(CVG)的保护伞下进行，CVG是一个拥有全校教职员工代表的行政单位。这项拟议的计划将集中于在任何时候培训三名博士前学生，他们已经选择了一名论文导师，并完成了一个强制性的助教学期。该计划将强调多学科和比较方法来研究发育基因组学。因此，17名经验丰富的教员将担任培训员，他们坚持这些原则。它们代表了一系列专业知识，包括经典发育生物学、功能基因组学、发育遗传学、复杂性状、统计遗传学和计算基因组学。他们的研究主要集中在脊椎动物上，包括老鼠、斑马鱼、狗、马和人类，但也代表了线虫和果蝇。他们还在脊椎动物发育和疾病的几个重要领域提供专业知识，包括神经生物学、生殖生物学、干细胞、器官发生、心脏疾病和功能、染色质结构和功能、移植后早期发育、胎儿宫内发育和疾病、衰老、发育进化、表观遗传学、营养基因组学以及癌症。为了准备NIH支持的计划，CVG在大学种子的支持下开发了培训范例和基础设施。二年级及以上的研究生将从校园内现有的几个研究生领域中挑选出来。选择将基于学生的学术和研究承诺，优先考虑那些进行合作或多学科研究的人。受训人员将被要求获得基因组学辅修学位，并参加与培训主题有关的若干活动，包括学生/伙伴组织的脊椎动物基因组学杂志俱乐部；发育生物学杂志俱乐部；“脊椎动物基因组学”(脊椎动物基因组学)研究系列；年度CVG专题讨论会；年度CVG电子海报会议；以及相关的外部会议和课程。除了他们的论文委员会外，学生的选择和他们的进步将由一个培训委员会监督。这项拟议的计划将在康奈尔大学新的生命科学倡议的背景下进行，这是该大学历史上最大的努力。加上致力于培训学术研究人员的特殊传统和对脊椎动物基因组学的有针对性的机构支持，该计划将为受训者提供一个出色的环境。 相关性：对疾病和出生缺陷的理解至关重要的是对发育的潜在分子和遗传机制有一个坚实的理解。这些基本机制已经通过对许多强大的模式生物的研究而阐明，并推论到人类身上。本课程将为学员提供对动物发育中重要问题的理解和欣赏，以及使用最先进的基因组学工具解决该领域的新前沿的经验。

DESCRIPTION (Provided by Applicant): Funding is requested to support a comprehensive training program in Vertebrate Developmental Genomics. The program will be conducted under the umbrella of Cornell University's Center for Vertebrate Genomics (CVG), an administrative unit with University-wide faculty representation. This proposed program will focus on training, at any one time, three predoctoral students who have chosen a thesis advisor and have finished one mandatory semester of teaching assistantship. The program will emphasize multidisciplinary and comparative approaches to studying developmental genomics. Accordingly, seventeen experienced faculty, who adhere to these tenets, will serve as trainers. They represent a gamut of expertise, including classical developmental biology, functional genomics, developmental genetics, complex traits, statistical genetics, and computational genomics. Their research concentrates primarily on vertebrate organisms, including mice, zebrafish, dog, horse, and humans, but also represented are C. elegans and Drosophila. They also provide expertise in several important areas of vertebrate development and disease, including neurobiology, reproductive biology, stem cells, organogenesis, heart disease & function, chromatin structure & function, early postimplantation development, intrauterine fetal development and disease, aging, evolution of development, epigenetics, nutritional genomics, as well as cancer. In preparation for an NIH supported program, the training paradigm and infrastructure has been developed by the CVG with University seed support. Graduate students in their 2nd year and beyond will be selected from several existing graduate fields across campus. Selection will be based upon academic and research promise of the student, with a preference for those conducting collaborative or multidisciplinary research. Trainees will be required to obtain a minor degree in Genomics, and participate in several activities related to the training theme, including the student/fellow-organized Vertebrate Genomics Journal Club; the Developmental Biology Journal Club; the "VERGE" (Vertebrate Genomics) research series; the annual CVG symposium; the annual CVG electronic poster session; as well as relevant external conferences and courses. Selection of students and monitoring of their progress will be overseen by a training committee, in addition to their thesis committee. This proposed program will take place in the context of Cornell University's new Life Sciences Initiative, the largest effort in its history. Coupled with an exceptional tradition of dedication to training academic researchers and targeted Institutional support for Vertebrate Genomics, this program will provide an outstanding environment for trainees. RELEVANCE: Critical to the understanding of disease and birth defects is a solid comprehension of the underlying molecular and genetic mechanisms of development. These basic mechanisms have been elucidated through the study of many powerful model organisms and extrapolated to humans. This program will provide trainees with a comprehension and appreciation of the important problems in animal development, and experience in using state-of-the-art genomics tools to address new frontiers in this area.