PGRN Administrative Coordination Hub, ACH (PGRN)

 描述(由申请人提供)：我们的项目旨在为新的PGRN建立一个行政协调中心(ACHPGRN)，该中心将加强科学交流，扩大在精确医学背景下理解药物反应的边界。ACHPGRN将采用最先进的技术来支持PGRN的会议和通信，并将建立一个具有面向公众的网络界面的基础设施，专注于招募多样化的新成员，鼓励和孵化新的合作，并向更广泛的科学、医疗和公共社区提供外联服务。ACHPGRN的目标是促进PGRN内部以及PGRN与整个科学界之间的交流与合作。为实现这一目标，ACHPGRN将支持三个主要领域的活动。第一个领域集中在科学会议上。ACHPGRN将为会议和网络研讨会提供高质量、可靠的后勤支持，促进以精准医学为重点的科学交流。第二个领域主要是开发一个PGRN网站，作为一个虚拟之家，其中将包括TED式的公开演示、每月新闻特写、出版物链接和播客采访，这些采访不断提供PGRN成就的最新披露。第三个领域侧重于通过在我们的会议上纳入联网机会和一个创新的开放提案平台来促进协作、协同作用的网络。该平台允许在PGRN社区提供广泛的科学投入的情况下制定研究建议。与第三个领域相结合，ACHPGRN将为获得大量资源的机会提供便利，这将使合作研究提案成为可能。特别是，ACHPGRN将为获取现有和新的PGRN建立的使能资源以及两个大型临床资源提供便利，这两个资源包含与DNA和其他样本有关的疾病和药物反应的表型信息。日本生物库拥有超过300,000个DNA样本，Kaiser Permanente的基因、环境和健康研究计划(RPGEH)现在包括来自100,000名参与者的样本，这些样本具有全基因组基因分型数据和来自电子医疗记录的大量表型信息。总体而言，我们的枢纽将为一个高度互动和协同的网络提供强有力的支持和领导，以推动科学发现 药物基因组学和精准医学。

 DESCRIPTION (provided by applicant): Our project aims to establish an Administrative Coordination Hub (ACHPGRN) for the new PGRN that will enhance scientific exchange and expand the boundaries of understanding drug response within the context of precision medicine. The ACHPGRN will employ state-of-the art technologies to support PGRN meetings, communications and will build an infrastructure with a public-facing web interface that focuses on recruiting a diverse new membership, encouraging and incubating nascent collaborations, and providing outreach to broader scientific, medical and public communities. The goal of the ACHPGRN is to catalyze communications and collaborations within the PGRN and between the PGRN and the scientific community at large. To achieve this goal, the ACHPGRN will support activities in three main areas. The first area is focused on scientific meetings. The ACHPGRN will provide high quality, reliable logistical support for meetings and webinars to promote scientific exchange focused on precision medicine. The second area centers primarily on the development of a PGRN website to serve as a virtual home that will include TED-style public presentations, monthly news features, publication links, and podcast interviews that continually provide an up-to-date disclosure of PGRN accomplishments. The third area focuses on catalyzing a collaborative, synergistic network by incorporating networking opportunities at our meetings and an innovative Open Proposals platform. This platform allows research proposals to be developed with broad scientific input from the PGRN community. In conjunction with the third area, the ACHPGRN will facilitate opportunities to access large resources that will enable the collaborative research proposals. In particular, the ACHPGRN will facilitate access to enabling resources established by the existing and new PGRN as well as to two large clinical resources that contain phenotypic information on disease and drug response linked to DNA and other samples. BioBank Japan has over 300,000 DNA samples and the Research Program on Genes, Environment and Health, RPGEH, of Kaiser Permanente now includes samples from 100,000 participants with genomewide genotyping data and extensive phenotypic information from the electronic medical record. Collectively, our hub will provide strong support and leadership for a highly interactive and synergistic network that advances scientific discoveries in pharmacogenomics and precision medicine.