Ghana Cancer Registry - from Hospital to Population: a Pilot Study

描述(申请人提供)：尽管传染病仍然是非洲的主要疾病负担，但仅基于非洲大陆约1%人口的初步数据表明，癌症发病率正在迅速增长--比发达国家快--而且非洲各地特定类型癌症的发病率差异很大。为了确定癌症控制和预防工作的特定重点领域，迫切需要高质量的癌症监测数据，这种数据来自区域和国家基于人口的癌症登记。为了满足西非国家加纳的这一需要，我们在此提议，作为第一步，在加纳首都和最大城市阿克拉最大的医院--Korle-Bu教学医院建立一个以医院为基础的癌症登记系统，以便为2009-2015年期间的全医院病例发现/报告制定有效的程序和培训(目标1)。我们将制定程序，将癌症登记处与现有的肿瘤档案联系起来，创建一个与登记处相连的肿瘤库，并加快对病理学审查的评估，以及为分子研究检索病理学材料(目标2)。最后，我们将调查阿克拉的其他医院 评估未来扩展到所有ACCR的基于人群的癌症登记的可行性(目标3)。我们的目标的成功完成将为阿克拉未来的基于人口的登记铺平道路，该登记将产生高质量的监测数据，以帮助加纳的癌症控制和预防工作。加纳的登记数据还可以用来与非洲裔美国人的癌症模式进行比较，以确定为什么非洲裔人会不成比例地受到特定类型的癌症的影响，如前列腺癌、肾癌和多发性骨髓瘤。

DESCRIPTION (provided by applicant): Although communicable diseases still represent the major disease burden in Africa, preliminary data based on just ~1% of the continent's population, suggests that cancer incidence is increasing rapidly - faster than in the developed world - and that rates for specific types of cancers vary widely across Africa. In order to identif specific areas of focus for cancer control and prevention efforts, there is a dire need for high-quality cancer surveillance data, the kind that come from regional and national population-based cancer registries. To address this need in the West African country of Ghana, we propose here, as a first step, a hospital-based cancer registry based at the Korle-Bu Teaching Hospital, the largest hospital in Accra, the capital and largest city in Ghana, to develop effective procedures and training for hospital-wide case-finding/reporting covering the period 2009-2015 (Aim 1). We will develop procedures to link the cancer registry with existing tumor archives to create a registry-linked tumor bank and expedite assessment of pathology review and retrieval of pathology materials for molecular studies (Aim 2). Finally, we will survey other hospitals in Accra to assess the feasibility of future expansion to a population based cancer registry for all of Accr (Aim 3). Successful completion of our Aims will pave the way for a future population-based registry in Accra that will generate high-quality surveillance data to aid the effort of cancer control and prevention in Ghana. The Ghana registry data can also be used to compare with cancer patterns on African Americans to identify why persons of African descent are disproportionally affected by specific types of cancers, such as that of the prostate, renal cell carcinoma, and multiple myeloma.