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Immune Modulation by Gammaherpesviruses

Immune Modulation by Gammaherpesviruses
伽玛疱疹病毒的免疫调节
批准号：
8886964
负责人：
LAURENT COSCOY
金额：
$25.72万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-09-14 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8886964
关键词：
Acquired Immunodeficiency SyndromeAffectAnimal ModelAnimalsAntiviral AgentsAntiviral ResponseAttenuatedB-LymphocytesBiologicalCD8B1 geneCodeCollaborationsDevelopmentDiseaseEquilibriumFluorescenceForcible intercourseHuman Herpesvirus 8Immune responseImmune systemImmunocompromised HostImmunomodulatorsIndividualInfectionKaposi SarcomaKnowledgeLifeLymphoproliferative DisordersMusPathogenesisPathologyPatientsPhysiologicalProteinsSatellite VirusesSkin CancerTechniquesTransplant RecipientsVaccinesViralVirusadaptive immunitydrug developmentgammaherpesvirusimmunoregulationimprovedprimary effusion lymphomaresponsetraffickingvaccine development

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中文摘要
翻译
描述（由申请人提供）： γ疱疹病毒，如KSHV和MHV 68，已经与宿主的免疫系统形成了微调平衡。因此，这些病毒在其宿主中建立终身持续感染，而不引起显著的病理。由这些病毒编码的免疫调节蛋白可能是这种平衡的关键调节剂。我们的建议集中在K3，一种由KSHV和MHV 68编码的蛋白质，它减弱了抗病毒CD8反应。我们的目标是了解这种蛋白质是如何调节的，以及我们是否可以规避其活性。我们相信，这些信息将被证明是有助于KSHV疫苗的发展。
英文摘要
DESCRIPTION (provided by applicant): Gammaherpesviruses, such as KSHV and MHV68, have developed a fine-tune equilibrium with the immune system of their host. As a result, these viruses establish a life-long persistent infection in their host without causing significant pathologies. Immunomodulatory proteins encoded by these viruses are likely to be critical regulators of this equilibrium. Our proposal focuses on K3, a protein encoded by KSHV and MHV68 that attenuates the antiviral CD8 responses. We aim to understand how this protein is regulated and whether we could circumvent its activity. We believe that this information will prove to be instrumental for the development of a KSHV vaccine.
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Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
Presentation of Qa-1 restricted peptides during homeostasis and viral infection
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