Critical Assessment of Structure Prediction Workshops

描述(申请人提供)：CASP实验和研讨会的目的是提供对大分子结构建模方法的独立评估。随着全基因组测序的成功，确定相应的DNA编码结构变得越来越重要。对蛋白质结构的广泛了解将大大有助于大分子功能、相互作用和生化途径的研究。它还将对生物学和人类疾病的理解产生重大影响，并最终对药物设计产生重大影响。尽管取得了实质性的进展，但结构的实验测定仍然固有地耗时和昂贵，并且提供了不到1%的已知序列的覆盖率。计算建模技术提供了更高比例的序列覆盖，尽管准确度较低。CASP的主要目标是确定当前从序列建模结构的方法的能力和局限性，以确定在哪里取得了进展，以及该领域在哪里受到特定瓶颈的阻碍。这些方法是在对大量蛋白质结构的盲目预测分析的基础上进行评估的。这些目标是通过每两年进行一次的一系列大规模社区试验和配套的讲习班来实现的。这些实验涉及来自20多个国家的100多个研究小组。在每个实验中，有两个初步研讨会负责计划和监测实验。主研讨会汇集了参与的科学家社区，对实验结果进行了深入的讨论和分析。这些讲习班的另一个目标是向初级学者和该领域的新手提供机会，使他们熟悉这一科学领域中最相关和最新的问题。履约协助方案讲习班不是一个典型的会议，而是社区试验的高潮。请求为第十一次、第十二次和第十三次履约协助方案实验的讲习班部分提供支助。

DESCRIPTION (provided by applicant): The purpose of the CASP experiments and workshops is to provide independent assessment of macromolecular structure modeling methods. With the success of genome-wide sequencing, determination of the corresponding DNA-encoded structures becomes increasingly important. Extensive knowledge of protein structures will significantly aid the investigation of macromolecular function, interactions, and biochemical pathways. It will also have a major impact on the understanding of biology and human disease, and eventually on drug design. In spite of substantial progress, experimental determination of structure remains inherently time-consuming and costly, and has provided coverage of less than 1% of the known sequences. Computational modeling techniques provide coverage of a much higher fraction of sequences, albeit at lower accuracy. The primary goals of CASP are to establish the capabilities and limitations of current methods of modeling structure from sequence, to determine where progress is being made, and where the field is held back by specific bottlenecks. Methods are assessed on the basis of the analysis of a large number of blind predictions of protein structure. These goals are achieved through a series of large-scale community experiments, conducted every two years, and accompanying workshops. The experiments involve well over 100 research groups from more than 20 countries. In each experiment, two preliminary workshops are concerned with planning and monitoring the experiment. The main workshop brings together the community of participating scientists for an intensive discussion and analysis of the results of the experiment. An additional goal of these workshops is to provide an opportunity to junior scholars and newcomers to the field to familiarize themselves with the most pertinent and most current issues in this area of science. The CASP workshops are not a typical conference but a culmination of the community experiment. Support is requested for the workshop component of the 11th, 12th and 13th CASP experiments.