Growth Hormone and Cardiovascular Disease

 描述（由申请人提供）：本项目的科学目标是研究相对生长激素（GH）缺乏在肥胖男性和女性骨丢失的病因学中的作用，以及GH可能影响骨微结构和强度的机制。该候选人是哈佛医学院的医学副教授和马萨诸塞州总医院的教员，他致力于以患者为导向的研究，并指导新的临床研究人员。她在第一个K24赠款期间有着以患者为导向的研究（POR）和指导的出色记录。这个K24竞争性续约申请的职业发展目标是支持候选人作为研究员和初级教师的POR导师的持续专业发展，她的长期目标是培养独立的POR研究人员。候选人的具体短期指导目标是：1）吸引和培训新学员，2）协助她目前的学员获得K和R赠款资金，发展自己的POR重点，并协助过渡到以POR为重点的独立职业的所有其他方面，3）获得额外的指导技能和3）继续和扩大教学课程，达到大量有兴趣追求POR职业的学员。候选人的NIH赠款将成为学员研究项目支持的基础。候选人在国家一级的指导方面具有领导记录，并在指导马萨诸塞州总医院（MGH）内分泌奖学金计划的学员和来自其他一些部门的学员方面具有成功的记录。MGH和哈佛医学院的机构环境非常出色，拥有非常强大的医学系，通过哈佛医学院获得临床转化科学中心拨款，以及MGH的临床研究计划，所有这些都提供了无数的教学机会，设施和支持。医学系对候选人做出了坚定的承诺，包括保护时间和专用空间。在以患者为导向的研究中的中期职业研究者奖是一个理想的机制，以确保必要的支持，以保护这位杰出导师的指导时间，否则她将不得不增加她的临床和行政责任，并确保候选人作为导师和临床研究人员的持续成功。

 DESCRIPTION (provided by applicant): The scientific goal of this project is to investigate the role of relative growth hormone (GH) deficiency in the etiopathology of bone loss in obese men and women, and the mechanisms by which GH may affect bone microarchitecture and strength. The candidate is an Associate Professor of Medicine at Harvard Medical School and a faculty member at Massachusetts General Hospital who is deeply committed to and highly qualified for a career in patient-oriented research and to mentor new clinician investigators. She has an outstanding record of patient-oriented research (POR) and mentoring during the first K24 grant period. The career development goal of this K24 competitive renewal application is to support the candidate's continued professional development as a POR mentor of fellows and junior faculty with her long-term goal of developing independent POR researchers. The candidate's specific short-term mentoring objectives are: 1) to attract and train new trainees, 2) assist her current mentees to obtain K and R grant funding, to develop their own POR focuses and assist with all other aspects of transitioning to independent careers focused on POR, 3) acquire additional mentoring skills and 3) continue and expand teaching in courses that reach a large number of trainees interested in pursuing POR careers. The candidate's NIH grants will form the basis of research project support for trainees. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and trainees from a number of other departments. The institutional environment is outstanding at the MGH and Harvard Medical School, with an extremely strong Department of Medicine, a Clinical Translational Science Center grant through Harvard Medical School, and a Clinical Research Program at the MGH, all of which offer a myriad of didactic opportunities, facilities and support. The Department of Medicine has made a strong commitment to the candidate, including protected time and dedicated space. The Midcareer Investigator Award in Patient-Oriented Research is an ideal mechanism to ensure the necessary support to protect time for mentorship for this outstanding mentor, who otherwise would have to increase her clinical and administrative responsibilities, and to ensure the candidate's continued success as a mentor and clinical researcher.